Sepsis remains an increasingly complex disease with vastly different health outcomes globally. It can be healthcare-associated and is often multi-drug resistant. Sepsis kills over 5000 Australians each year and accounts for one in four ICU deaths. Current diagnostic approaches are inadequate when time is critical. In this webinar, leading researchers present the latest data and studies on treatment interventions, diagnostic considerations, combination antimicrobial therapy, and nebulised antimicrobials; also pharmacokinetics and optimisation of antimicrobials for the treatment of sepsis, and the role of therapeutic drug monitoring.