Professor Jason Roberts

Featured projects	Duration
PK studies of antimicrobials in patients with VAP, CAP/ PK of antimicrobials National Health and Medical Research Council
Exploring the impact of altered and variable antimicrobial pharmacokinetics on bacterial killing and emergence of bacterial resistance. National Health and Medical Research Council
Continuous versus intermittent beta-lactams administration in critically ill patients with sepsis not receiving renal replacement therapy.
PK/PD of antimicrobials in other 'at risk patient groups
Antibiotic penetration into epithelial lining fluid of mechanically ventilated patients with VAP and CAP.
Therapeutic drug monitoring and dose personalisation of antimicrobials in mechanically ventilated patients with Gram-negative pneumonia.
Therapeutic Drug Monitoring National Health and Medical Research Council
Exploring population variability of antimicrobial epithelial lining fluid penetration in patients with VAP.
Development of clinical practice guidelines on antimicrobial dosing incorporating new knowledge generated by the CRE REDUCE.
BLING III: A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients National Health and Medical Research Council
SaMpling Antibiotics in Renal Replacement Therapy (SMARRT). National Health and Medical Research Council
Dose optimisation of anti-infectives in patients post-lung transplant
Ex Vivo renal replacement therapy study to quantify the effect of differing RRT settings on antimicrobial clearance.
Beta-lactam antibiotic dose optimisation in critically ill patients
Antimicrobial pharmacokinetics in patients with cystic fibrosis, lung and bone marrow transplant. National Health and Medical Research Council
Dose optimisation of antifungals and antivirals in post-lung transplant patients
Pharmacokinetics of Flucloxacillin and Lincomycin in burns patients. National Health and Medical Research Council
Using laboratory-based infection models to develop better antibiotic dosing regimens
Pharmacokinetics of antifungals in intensive care patients. National Health and Medical Research Council
Anti-infective drugs
Pharmacokinetics of antimicrobials in critically ill obese patients National Health and Medical Research Council
Sedatives and analgesics
Pharmacometric analysis of antimicrobial pharmacokinetics to propose novel and innovative dosing regimens. National Health and Medical Research Council
Dose optimisation of anti-infective drugs in extracorporeal membrane oxygenation (ECMO) - co-sponsored by CRE ACTIONS
Therapeutic drug monitoring optimisation of antimicrobial exposures for critically ill, burns and transplant patients.

Jamal, Janattul-Ain, Abdul-Aziz, Mohd-Hafiz, Levkovich, Bianca and Roberts, Jason A. (2019). Clinical pharmacy considerations in ICU. In Zaheer-Ud-Din Babar (Ed.), Encyclopedia of pharmacy practice and clinical pharmacy (pp. 849-865) Oxford, United Kingdom: Elsevier. doi:10.1016/B978-0-12-812735-3.00576-8

Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2018). Preface. In Andrew A. Udy, Jason A. Roberts and Jeffrey Lipman (Ed.), Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically Ill (pp. v-vii) Singapore, Singapore: Springer Singapore. doi:10.1007/978-981-10-5336-8

Sime, Fekade B. and Roberts, Jason A. (2018). Appropriate antimicrobial therapy in critically ill patients. In Massimo Sartelli, Matteo Bassetti and Ignacio Martin-Loeches (Ed.), Abdominal Sepsis: a multidisciplinary approach (pp. 319-342) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-59704-1_21

Sime, Fekade B. and Roberts, Jason A. (2018). Antibiotic pharmacodynamics. In Andrew Udy, Jason A. Roberts and Jeffrey Lipman (Ed.), Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill (pp. 17-29) Singapore, Singapore: Springer Nature. doi:10.1007/978-981-10-5336-8_2

Geddes, Alasdair M., Gould, Ian M., Roberts, Jason A., Trubiano, Jason A. and Lindsay Grayson, M. (2017). Benzylpenicillin (penicillin G). In M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson (Ed.), Kucers’ the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs 7th ed. (pp. 23-91) Boca Raton, FL, United States: CRC Press. doi:10.1201/9781315152110

Sinnollareddy, Mahipal G., Cotta, Menino O. and Roberts, Jason A. (2017). Pharmacokinetic and pharmacodynamic tools to increase efficacy. In Celine Pulcini, Önder Ergönül, Füsun Can and Bojana Beović (Ed.), Developments in emerging and existing infectious diseases: Antimicrobial stewardship (pp. 85-98) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-810477-4.00007-6

Geddes, Alasdair M., Gould, Ian M. and Roberts, Jason A. (2017). Phenoxypenicillins. In M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson (Ed.), Kucers’ the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs 7th ed. (pp. 92-99) Boca Raton, FL, United States: CRC Press. doi:10.1201/9781315152110

Abdul-Aziz, M. H., Shekar, Kiran and Roberts, Jason A. (2017). Antibiotic dosing during extracorporeal membrane oxygenation. In Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill (pp. 151-171) Gateway East, Singapore: Springer Singapore. doi:10.1007/978-981-10-5336-8_8

Denny, Kerina J., Lipman, Jeffrey and Roberts, Jason A. (2017). Cephalothin and cefazolin. In Kucers the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs, seventh edition (pp. 347-360) Boca Raton, FL, United States: CRC Press. doi:10.1201/9781315152110

Geddes, Alasdair M., Gould, Ian M., Roberts, Jason A., Lindsay Grayson, M. and Cosgrove, Sara E. (2017). Ampicillin and amoxicillin. In M. Lindsay Grayson, Sara E. Cosgrove, Suzanne Crowe, William Hope, James S. McCarthy, John Mills, Johan W. Mouton and David L. Paterson (Ed.), Kucers’ the use of antibiotics: a clinical review of antibacterial, antifungal, antiparasitic, and antiviral drugs 7th ed. (pp. 100-135) Boca Raton, FL, United States: CRC Press. doi:10.1201/9781315152110

Thorley, Bruce R. and Roberts, Jason A. (2016). Isolation and characterization of poliovirus in cell culture systems. In Javier Martin (Ed.), Poliovirus: methods and protocols (pp. 29-53) New York, United States: Humana Press. doi:10.1007/978-1-4939-3292-4_4

Jamal, Janattul-Ain and Roberts, Jason A. (2016). Polyene antifungals. In Syed Tabish R. Zaidi and Jason A. Roberts (Ed.), Drug Dosing in Obesity: Volume I: Antimicrobials (pp. 109-115) Cham, Switzerland: Springer. doi:10.1007/978-3-319-44034-7_10

Jamal, Janattul-Ain and Roberts, Jason A. (2016). Aminoglycoside dosing in obesity. In Syed Tabish R. Zaidi and Jason A. Roberts (Ed.), Drug Dosing in Obesity: Volume I: Antimicrobials (pp. 39-44) Cham, Switzerland: Springer International Publishing. doi:10.1007/978-3-319-44034-7_4

Sinnollareddy, Mahipal G. and Roberts, Jason A. (2016). Pharmacodynamic considerations in critically ill patients. In John C. Rotschafer, David R. Andes and Keith A. Rodvold (Ed.), Antibiotic pharmacodynamics (pp. 537-560) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-3323-5_21

Osbert Cotta, Menino and Roberts, Jason (2016). Pharmacokinetic and pharmacodynamic principles of antimicrobials. In Matthew Laundy, Mark Gilchrist and Laura Whitney (Ed.), Antimicrobial stewardship (pp. 71-78) Oxford, United Kingdom: Oxford University Press. doi:10.1093/med/9780198758792.003.0009

Ulldemolins, Marta and Roberts, Jason A. (2012). How do I adjust antimicrobial daily dosage in patients with MODS? a pharmacist’s contribution. In Jordi Rello, Jeffrey Lipman and Thiago Lisboa (Ed.), Sepsis management: PIRO and MODS (pp. 199-216) Berlin, Germany: Springer.

Roberts, Jason A. and Thorley, Bruce R. (2010). Enterovirus. In PCR for Clinical Microbiology: An Australian and International Perspective (pp. 229-233) : Springer Netherlands. doi:10.1007/978-90-481-9039-3_32

Ulldemolins, M., Roberts, J. A. and Rello, J. (2010). Drug distribution: is it a more important determinant of drug dosing than clearance?. In Intensive care medicine: annual update 2010 (pp. 507-516) Brussels, Belgium: Springer. doi:10.1007/978-1-4419-5562-3_47

Ulldemolins, Marta, Roberts, Jason, Varghese, Julie and Lipman, Jeffrey (2010). Antibiotic dosing in critically ill patients. In Vineet Nayar, J. V. Peter, Roop Kishen and S. Srinivas (Ed.), Critical Care Update 2009 (pp. 128-142) Daryaganj, New Delhi, India: Jaypee Brothers Medical Publishers.

Udy, Andrew, Roberts, Jason and Lipman, Jeffrey (2010). Augmented renal clearance: Unraveling the mystery of elevated antibiotic clearance. In J.-L. Vincent (Ed.), Yearbook of Intensive Care and Emergency Medicine 2010 (pp. 495-506) Brussels, Belgium: Springer Verlag. doi:10.1007/978-3-642-10286-8

Varghese, Julie M., Roberts, Jason A. and Lipman, Jeffrey (2009). Avoiding toxicity of antibiotics. In Jean-Daniel Chiche and Leanne M. Aitken (Ed.), Patient safety and quality of care in intensive care medicine (pp. 291-304) Berlin, Germany: Medizinisch Wissenschaftliche Verlagsgesellschaft.

Udy, Andrew, Roberts, Jason, Boots, Robert and Lipman, Jeffrey (2008). Dose adjustment and pharmacodynamic considerations for antibiotics in severe sepsis and septic Shock. In Sepsis: New Strategies for Management (pp. 97-136) : Springer Berlin Heidelberg. doi:10.1007/978-3-540-79001-3_8

Udy, Andrew, Roberts, Jason A., Boots, Robert J. and Lipman, Jeffrey (2008). Dose adjustment and pharmacodynamic considerations for antibiotics in severe sepsis and septic shock. In Jordi Rello and Marcos I. Restrepo (Ed.), Sepsis: New strategies for management (pp. 97-102) London: Springer-Verlag. doi:10.1007/978-3-540-79001-3

Roberts, J. A. and Lipman, J. (2007). Dose adjustment and pharmacokinetics of antibiotics in severe sepsis and septic shock. In Jordi Rello, Marin Kollef, Emili Diaz and Alejandro Rodriguez (Ed.), Infectious diseases in critical care 2nd ed. (pp. 122-146) Berlin, Germany; New York, U.S.A.: Springer. doi:10.1007/978-3-540-34406-3_12

Abbott, Iain J., van Gorp, Elke, Wijma, Rixt A., Meletiadis, Joseph, Roberts, Jason A., Mouton, Johan W. and Peleg, Anton Y. (2020) Oral fosfomycin efficacy with variable urinary exposures following single and multiple doses against Enterobacterales: the importance of heteroresistance on growth outcome. Antimicrobial Agents and Chemotherapy, . doi:10.1128/aac.01982-19

Yadav, Rajbharan, Bergen, Phillip J., Rogers, Kate E., Kirkpatrick, Carl M. J., Wallis, Steven C., Huang, Yuling, Bulitta, Jürgen B., Paterson, David L., Lipman, Jeffrey, Nation, Roger L., Roberts, Jason A. and Landersdorfer, Cornelia B. (2020) Meropenem-tobramycin combination regimens combat carbapenem-resistant Pseudomonas aeruginosa in the hollow-fiber infection model simulating augmented renal clearance in critically ill patients. Antimicrobial Agents and Chemotherapy, 64 1: . doi:10.1128/aac.01679-19

Lai, Tony, Alffenaar, Jan-Willem, Kesson, Alison, Bandodkar, Sushil and Roberts, Jason A (2019) Evaluation of target attainment of oral posaconazole suspension in immunocompromised children. Journal of Antimicrobial Chemotherapy, . doi:10.1093/jac/dkz481

Leone, Marc, Roberts, Jason A., Bassetti, Matteo, Bouglé, Adrien, Lavigne, Jean-Philippe, Legrand, Matthieu, Neely, Michael, Paiva, José-Artur, Payen, Didier, Rello, Jordi, Roger, Claire, Sjövall, Fredrik and Jung, Boris (2019) Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Anaesthesia Critical Care and Pain Medicine, 38 6: 647-656. doi:10.1016/j.accpm.2019.09.009

Dhaese, S.A.M., Colin, P., Willems, H., Heffernan, A., Gadeyne, B., Van Vooren, S., Depuydt, P., Hoste, E., Stove, V., Verstraete, A.G., Lipman, J., Roberts, J.A. and De Waele, J.J. (2019) Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion. International Journal of Antimicrobial Agents, 54 6: 741-749. doi:10.1016/j.ijantimicag.2019.08.024

Tabah, Alexis, Bassetti, Matteo, Kollef, Marin H., Zahar, Jean-Ralph, Paiva, José-Artur, Timsit, Jean-Francois, Roberts, Jason A., Schouten, Jeroen, Giamarellou, Helen, Rello, Jordi, De Waele, Jan, Shorr, Andrew F., Leone, Marc, Poulakou, Garyphallia, Depuydt, Pieter and Garnacho-Montero, Jose (2019) Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP). Intensive Care Medicine, . doi:10.1007/s00134-019-05866-w

Abdul-Aziz, Mohd H. and Roberts, Jason A. (2019) Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter?. Current Opinion in Anaesthesiology, . doi:10.1097/aco.0000000000000810

Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2019) A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study. Analytical and Bioanalytical Chemistry, . doi:10.1007/s00216-019-02184-4

Baptista, João Pedro, Roberts, Jason A., Sousa, Eduardo, Freitas, Ricardo, Devesa, Nuno and Pimentel, Jorge (2019) Attainment of therapeutic vancomycin level within the first 24 h: authors' response. Critical Care, 23 1: 354. doi:10.1186/s13054-019-2639-7

Pandey, Saurabh, Dhanani, Jayesh, Lipman, Jeffrey, Roberts, Jason A., Wallis, Steve C. and Parker, Suzanne L. (2019) Development and validation of LC-MS/MS methods to measure tobramycin and lincomycin in plasma, microdialysis fluid and urine: application to a pilot pharmacokinetic research study. Clinical Chemistry and Laboratory Medicine, . doi:10.1515/cclm-2019-0780

Boidin, Clément, Bourguignon, Laurent, Cohen, Sabine, Roger, Claire, Lefrant, Jean-Yves, Roberts, Jason A., Allaouchiche, Bernard, Lepape, Alain, Friggeri, Arnaud and Goutelle, Sylvain (2019) Amikacin initial dose in critically ill patients: a nonparametric approach to optimize a priori pharmacokinetic/pharmacodynamic target attainments in individual patients. Antimicrobial Agents and Chemotherapy, 63 11: e00993-19. doi:10.1128/aac.00993-19

Heffernan, Aaron James, Sime, Fekade Bruck, Sun, Jing, Lipman, Jeffrey, Kumar, Anand, Andrews, Katherine, Ellwood, David, Grimwood, Keith and Roberts, Jason (2019) β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2019.10.020

Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2019) Pharmacokinetics of total and unbound cefazolin during veno-arterial extracorporeal membrane oxygenation: a case report. Chemotherapy, 64 3: 1-4. doi:10.1159/000502474

Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019) A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration. Antimicrobial Agents and Chemotherapy, . doi:10.1128/aac.01655-19

Fox, Emma, Cheng, Vesa, Rawlins, Matthew, Dyer, John, De Keulenaer, Bart, Page, Michael M., Hoad, Kirsten and Roberts, Jason (2019) Pharmacokinetics of flucloxacillin during prolonged intermittent renal replacement therapy in a 76-year-old man. Journal of Chemotherapy, . doi:10.1080/1120009X.2019.1681622

Abdul-Aziz, Mohd H., Shekar, Kiran and Roberts, Jason A. (2019) Antimicrobial therapy during ECMO – customised dosing with therapeutic drug monitoring: the way to go?. Anaesthesia Critical Care and Pain Medicine, 38 5: 451-453. doi:10.1016/j.accpm.2019.07.005

Mohd Sazlly, Lim S, Zainal Abidin, A., Liew, S.M., Roberts, J.A. and Sime, FB (2019) The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis. Journal of Infection, . doi:10.1016/j.jinf.2019.09.012

Douville, S. E., Callaway, L. K., Amoako, A., Roberts, J. and Eley, V. A. (2019) Reducing post-caesarean delivery surgical site infections: a narrative review. International Journal of Obstetric Anesthesia, . doi:10.1016/j.ijoa.2019.08.007

Dhaese, Sofie A. M., Roberts, Jason A., Carlier, Mieke, Verstraete, Alain G., Stove, Veronique and De Waele, Jan J. (2019) Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients (vol 51, pg 594, 2018). International Journal of Antimicrobial Agents, 54 3: 380-380. doi:10.1016/j.ijantimicag.2019.07.022

Gurunathan, Usha, Parker, Suzanne L., Maguire, Richard, Ramdath, Dale, Bijoor, Manu, Wallis, Steven C. and Roberts, Jason A. (2019) Population pharmacokinetics of periarticular ketorolac in adult patients undergoing total hip or total knee replacement surgery. Anesthesia and Analgesia, 129 3: 701-708. doi:10.1213/ANE.0000000000003377

Dhaese, Sofie A.M., Roberts, Jason A., Carlier, M., Verstraete, Alain G., Stove, Veronique and DeWaele, J. J. (2019) Corrigendum to ‘Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients’ (International Journal of Antimicrobial Agents (2018) 51(4) (594–600), (S0924857917304491), (10.1016/j.ijantimicag.2017.12.015)). International Journal of Antimicrobial Agents, 54 2: 271-271. doi:10.1016/j.ijantimicag.2019.07.007

T.P. Wan, Winnie, Guerra Valero, Yarmarly, Choi, Gordon Y.S., Ordóñez Mejia, Jenny L., Wallis, Steven C., Joynt, Gavin M., Lipman, Jeffrey, Gomersall, Charles D. and Roberts, Jason A. (2019) In-vitro adsorption and sieving coefficient of ticarcillin-clavulanate during continuous haemofiltration. International Journal of Antimicrobial Agents, 54 2: 261-264. doi:10.1016/j.ijantimicag.2019.03.018

Dhaese, Sofie A.M., Thooft, Alexander D.J., Farkas, Andras, Lipman, Jeffrey, Verstraete, Alain G., Stove, Veronique, Roberts, Jason A. and De Waele, Jan J. (2019) Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: a prospective observational study. Journal of Critical Care, 52 75-79. doi:10.1016/j.jcrc.2019.04.013

Baptista, João Pedro, Roberts, Jason A. and Udy, Andrew A. (2019) Augmented renal clearance: A real phenomenon with an uncertain cause. Anaesthesia Critical Care and Pain Medicine, 38 4: 335-336. doi:10.1016/j.accpm.2019.03.002

Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019) Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction. Antimicrobial Agents and Chemotherapy, 63 10: . doi:10.1128/aac.01265-19

Sumi, Chandra Datta, Heffernan, Aaron J., Lipman, Jeffery, Roberts, Jason A. and Sime, Fekade B. (2019) What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram‑Negative Bacteria? A Systematic Review. Clinical Pharmacokinetics, . doi:10.1007/s40262-019-00791-z

Weber, Nicholas, Jackson, Kathryn, McWhinney, Brett, Ungerer, Jacobus, Kennedy, Glen, Lipman, Jeffrey and Roberts, Jason A. (2019) Evaluation of pharmacokinetic/pharmacodynamic and clinical outcomes with 6-hourly empiric piperacillin-tazobactam dosing in hematological malignancy patients with febrile neutropenia. Journal of Infection and Chemotherapy, 25 7: 503-508. doi:10.1016/j.jiac.2019.02.014

Cheng, Vesa, Rawlins, Matthew, Chang, Tim, Fox, Emma, Dyer, John, Allen, Chris, Litton, Edward, Page, Michael M., Hoad, Kirsten and Roberts, Jason A. (2019) Pharmacokinetics of benzylpenicillin (penicillin G) during prolonged intermittent renal replacement therapy. Chemotherapy, 64 1: 1-5. doi:10.1159/000499375

Economou, Caleb J. P., Xie, Jiao, Comadira, Gregory, Richards, Brent, Tallott, Mandy, Wallis, Steven C., Ordoñez, Jenny, Lipman, Jeffrey and Roberts, Jason A. (2019) Population pharmacokinetics of ticarcillin in critically ill patients receiving extended daily diafiltration. International Journal of Antimicrobial Agents, 54 3: 351-355. doi:10.1016/j.ijantimicag.2019.06.027

Ranganathan, Dwarakanathan, Abdul-Aziz, Mohd H., John, George T., McWhinney, Brett C., Fassett, Robert G., Healy, Helen, Kubler, Paul, Lim, Aaron, Lipman, Jeffrey, Purvey, Megan, Roberts, Matthew, Reyaldeen, Reza, Ungerer, Jacobus and Roberts, Jason A. (2019) Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN). Therapeutic Drug Monitoring, 1. doi:10.1097/ftd.0000000000000658

Sime, Fekade B., Byrn, Catherine J., Parker, Suzanne, Stuart, Janine, Butler, Jenie, Starr, Therese, Pandey, Saurabh, Wallis, Steven C., Lipman, Jeffery and Roberts, Jason A. (2019) Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients. Critical Care, . doi:10.1186/s13054-019-2483-9

Hagel, Stefan, Fiedler, Sandra, Hohn, Andreas, Brinkmann, Alexander, Frey, Otto R., Hoyer, Heike, Schlattmann, Peter, Kiehntopf, Michael, Roberts, Jason A., Pletz, Mathias W., Bloos, Frank, Angermair, Stefan, Bracht, Hendrik, Barth, Eberhard, Kluge, Stefan, Nierhaus, Axel, Motsch, Johann, Brenner, Thorsten, Annecke, Thorsten, Bach, Friedhelm, Weigand, Markus, Schappacher, Markus, Von Ameln-Mayerhofer, Andreas, Michels, Guido, Roehr, Anka, Fuchs, Thomas, Eichner, Sarah, Köng, Christina, Pinder, Nadine, Müller, Carsten, Petersen, Miriam, Steinbach, Gerald, Jarczak, Dominik, Weisman, DIrk, Kurlbaum, Max and Braune, Anke (2019) Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial. Trials, 20 1: 330. doi:10.1186/s13063-019-3437-x

Dhanani, Jayesh A., Roberts, Jason and Reade, Michael C (2019) Nebulized tranexamic acid therapy for hemoptysis associated with submassive pulmonary embolism. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 32 . doi:10.1089/jamp.2019.1534

Heffernan, A. J., Germano, A., Sime, F. B., Roberts, Jason A. and Kimura, E. (2019) Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?. European Journal of Clinical Pharmacology, . doi:10.1007/s00228-019-02694-1

Schetz, Miet, De Jong, Audrey, Deane, Adam M., Druml, Wilfried, Hemelaar, Pleun, Pelosi, Paolo, Pickkers, Peter, Reintam-Blaser, Annika, Roberts, Jason, Sakr, Yasser and Jaber, Samir (2019) Obesity in the critically ill: a narrative review. Intensive Care Medicine, 45 6: 757-769. doi:10.1007/s00134-019-05594-1

Colin, Pieter J., Allegaert, Karel, Thomson, Alison H., Touw, Daan J., Dolton, Michael, de Hoog, Matthijs, Roberts, Jason A., Adane, Eyob D., Yamamoto, Masato, Santos-Buelga, Dolores, Martín-Suarez, Ana, Simon, Nicolas, Taccone, Fabio S., Lo, Yoke-Lin, Barcia, Emilia, Struys, Michel M. R. F. and Eleveld, Douglas J. (2019) Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations. Clinical Pharmacokinetics, 58 6: 767-780. doi:10.1007/s40262-018-0727-5

Tenorio-Cañamás, Teresa, Grau, Santiago, Luque, Sonia, Fortún, Jesús, Liaño, Fernando and Roberts, Jason A. (2019) Pharmacokinetics of micafungin in critically ill patients receiving continuous venovenous hemodialysis with high cutoff membranes. Therapeutic Drug Monitoring, 41 3: 376-382. doi:10.1097/FTD.0000000000000595

Roberts, Jason A., Alobaid, Abdulaziz S., Wallis, Steven C., Perner, Anders, Lipman, Jeffrey and Sjövall, Fredrik (2019) Defining optimal dosing of ciprofloxacin in patients with septic shock. Journal of Antimicrobial Chemotherapy, 74 6: 1662-1669. doi:10.1093/jac/dkz069

O'Brien, Daniel W., Cotta, Menino O., Choo, Lyn, Fowler, Stephen, Downey, Maria, Fisquet, Stephanie, Tan, Ivy and Roberts, Jason A. (2019) Dexmedetomidine prescribing in Australian intensive care units: an observational study. Journal of Pharmacy Practice and Research, . doi:10.1002/jppr.1529

Guerra Valero, Yarmarly C., Roberts, Jason A., Lipman, Jeffrey, Fourie, Cheryl, Starr, Therese, Wallis, Steven C. and Parker, Suzanne L. (2019) Analysis of capillary microsamples obtained from a skin-prick to measure vancomycin concentrations as a valid alternative to conventional sampling: a bridging study. Journal of Pharmaceutical and Biomedical Analysis, 169 288-292. doi:10.1016/j.jpba.2019.03.018

Jager, Nynke G. L., van Hest, Reinier M., Lipman, Jeffrey, Roberts, Jason A. and Cotta, Menino O. (2019) Antibiotic exposure at the site of infection: principles and assessment of tissue penetration. Expert Review of Clinical Pharmacology, 12 7: 623-634. doi:10.1080/17512433.2019.1621161

Dhanani, Jayesh A., Diab, Sara, Chaudhary, Jivesh, Cohen, Jeremy, Parker, Suzanne L., Wallis, Steven C., Boidin, Clément, Barnett, Adrian, Chew, Michelle, Roberts, Jason A. and Fraser, John F. (2019) Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model. Anesthesiology, 131 2: 1-355. doi:10.1097/ALN.0000000000002752

Roberts, Jason A., Roger, Claire and De Waele, Jan J. (2019) Personalized antibiotic dosing for the critically ill. Intensive Care Medicine, 45 5: 715-718. doi:10.1007/s00134-019-05522-3

Zhang, Ping, Curley, Cameron I., Mudie, Kari, Nakagaki, Midori, Hill, Geoffrey R., Roberts, Jason A. and Tey, Siok-Keen (2019) Effect of plasmapheresis on ATG (Thymoglobulin) clearance prior to adoptive T cell transfer. Bone Marrow Transplantation, . doi:10.1038/s41409-019-0505-5

Lim, Sazlyna Mohd Sazlly, Sime, Fekade Bruck and Roberts, Jason (2019) Multidrug-resistant Acinetobacter baumannii infections: current evidence on treatment options and role of PK/PD in dose optimization. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2019.02.016

Dimopoulos, George, Koulenti, Despoina, Parker, Suzanne L, Roberts, Jason A, Arvaniti, Kostoula and Poulakou, Garyphalia (2019) Intravenous fosfomycin for the treatment of multidrug resistant pathogens: what is the evidence on dosing regimens?. Expert Review of Anti-infective Therapy, 17 3: 201-210. doi:10.1080/14787210.2019.1573669

Paul, Sanjoy Ketan, Roberts, Jason A., Lipman, Jeffrey, Deans, Renae and Samanta, Mayukh (2019) A robust statistical approach to analyse population pharmacokinetic data in critically ill patients receiving renal replacement therapy. Clinical Pharmacokinetics, 58 2: 263-270. doi:10.1007/s40262-018-0690-1

Cheng, Vesa, Abdul-Aziz, Mohd H., Roberts, Jason A. and Shekar, Kiran (2019) Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients. Expert Opinion on Drug Metabolism & Toxicology, 15 2: 1-10. doi:10.1080/17425255.2019.1563596

Dhaese, Sofie A M, Farkas, Andras, Colin, Pieter, Lipman, Jeffrey, Stove, Veronique, Verstraete, Alain G, Roberts, Jason A and De Waele, Jan J (2019) Population pharmacokinetics and evaluation of the predictive performance of pharmacokinetic models in critically ill patients receiving continuous infusion meropenem: a comparison of eight pharmacokinetic models. Journal of Antimicrobial Chemotherapy, 74 2: 432-441. doi:10.1093/jac/dky434

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Maqbool, Faheem, Roberts, Jason A. and Falconer, James Robert (2019) Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today, 24 3: 858-866. doi:10.1016/j.drudis.2019.01.004

Kanji, Salmaan, Roberts, Jason A., Xie, Jiao, Zelenitsky, Sheryl, Hiremath, Swapnil, Zhang, Guijun, Watpool, Irene, Porteous, Rebecca and Patel, Rakesh (2019) Vancomycin Population Pharmacokinetics in Critically Ill Adults During Sustained Low-Efficiency Dialysis. Clinical Pharmacokinetics, . doi:10.1007/s40262-019-00817-6

Williams, Paul, Cotta, Menino Osbert and Roberts, Jason A. (2019) Pharmacokinetics/Pharmacodynamics of β-Lactams and therapeutic drug monitoring: from theory to practical issues in the intensive care unit. Seminars in Respiratory and Critical Care Medicine, 40 4: 476-487. doi:10.1055/s-0039-1693498

Mabilat, Claude, Gros, Marie Francoise, Nicolau, David, Mouton, Johan W., Textoris, Julien, Roberts, Jason A., Cotta, Menino O., van Belkum, Alex and Caniaux, Isabelle (2019) Diagnostic and medical needs for therapeutic drug monitoring of antibiotics. European Journal of Clinical Microbiology and Infectious Diseases, . doi:10.1007/s10096-019-03769-8

Donnellan, Sine, Wright, Daniel F. B., Roberts, Jason A., Duffull, Stephen B., Schollum, John B. W., Putt, Tracey L., Wallis, Steven C. and Walker, Robert J. (2019) The pharmacokinetics of meropenem and piperacillin-tazobactam during sustained low efficiency haemodiafiltration (SLED-HDF). European Journal of Clinical Pharmacology, . doi:10.1007/s00228-019-02792-0

Williams, Paul, Beall, Gareth, Cotta, Menino Osbert and Roberts, Jason A. (2019) Antimicrobial dosing in critical care: A pragmatic adult dosing nomogram. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2019.10.018

Raby, Edward, Naicker, Saiyuri, Sime, Fekade Bruck, Manning, Laurens, Wallis, Steven C., Pandey, Saurabh and Roberts, Jason A. (2019) Ceftolozane-tazobactam in an elastomeric infusion device for ambulatory care: An in vitro stability study. European Journal of Hospital Pharmacy , . doi:10.1136/ejhpharm-2019-002093

Richter, Daniel C., Frey, Otto, Röhr, Anka, Roberts, Jason A., Köberer, Andreas, Fuchs, Thomas, Papadimas, Nikolaos, Heinzel-Gutenbrunner, Monika, Brenner, Thorsten, Lichtenstern, Christoph, Weigand, Markus A. and Brinkmann, Alexander (2019) Therapeutic drug monitoring-guided continuous infusion of piperacillin/tazobactam significantly improves pharmacokinetic target attainment in critically ill patients: a retrospective analysis of four years of clinical experience. Infection, 47 6: 1001-1011. doi:10.1007/s15010-019-01352-z

Kerz, Thomas, Von Loewenich, Friederike D., Roberts, Jason, Neulen, Axel and Ringel, Florian (2018) Cerebrospinal fluid penetration of very high-dose meropenem: a case report. Annals of Clinical Microbiology and Antimicrobials, 17 1: 47. doi:10.1186/s12941-018-0299-0

Jamal, Janattul-Ain, Roger, Claire and Roberts, Jason A. (2018) Understanding the impact of pathophysiological alterations during critical illness on drug pharmacokinetics. Anaesthesia Critical Care & Pain Medicine, 37 6: 515-517. doi:10.1016/j.accpm.2018.10.006

Toulouse, Elisabeth, Masseguin, Christophe, Lafont, Brigitte, McGurk, Gordon, Harbonn, Anna, Roberts, Jason A., Granier, Sophie, Dupeyron, Arnaud and Bazin, Jean Etienne (2018) French legal approach to clinical research. Anaesthesia Critical Care and Pain Medicine, 37 6: 607-614. doi:10.1016/j.accpm.2018.10.013

Heffernan, Aaron J., Sime, Fekade B., Lipman, Jeffrey, Dhanani, Jayesh, Andrews, Katherine, Ellwood, David, Grimwood, Keith and Roberts, Jason A. (2018) Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2018.11.011

Rawlins, Matthew, Cheng, Vesa, Raby, Edward, Dyer, John, Regli, Adrian, Ingram, Paul, McWhinney, Brett C., Ungerer, Jacobus P. J. and Roberts, Jason A. (2018) Pharmacokinetics of ceftolozane-tazobactam during prolonged intermittent renal replacement therapy. Chemotherapy, 63 4: 203-206. doi:10.1159/000493196

Heffernan, Aaron J., Sime, Fekade B., Taccone, Fabio S. and Roberts, Jason A. (2018) How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients. Current Opinion in Infectious Diseases, 1. doi:10.1097/QCO.0000000000000494

Abraham, Jacob, Sinnollareddy, Mahipal G., Roberts, Michael S., Williams, Patricia, Peake, Sandra L., Lipman, Jeffrey and Roberts, Jason A. (2018) Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically ill patients with sepsis. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2018.09.021

Sime, Fekade B., Stuart, Janine, Butler, Jenie, Starr, Therese, Wallis, Steven C., Pandey, Saurabh, Lipman, Jeffrey and Roberts, Jason A. (2018) A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration. International Journal of Antimicrobial Agents, 52 4: 506-509. doi:10.1016/j.ijantimicag.2018.07.008

Sime, Fekade B., Pandey, Saurabh, Karamujic, Nermin, Parker, Suzanne, Alexander, Elizabeth, Loutit, Jeffery, Durso, Stephanie, Griffith, David, Lipman, Jeffrey, Wallis, Steven C. and Roberts, Jason A. (2018) Ex vivo characterization of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam. Antimicrobial Agents and Chemotherapy, 62 10: . doi:10.1128/AAC.01306-18

Wong, Gloria, Briscoe, Scott, McWhinney, Brett, Ally, Mumtaz, Ungerer, Jacobus, Lipman, Jeffrey and Roberts, Jason A (2018) Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures. Journal of Antimicrobial Chemotherapy, 73 11: 3087-3094. doi:10.1093/jac/dky314

Sime, Fekade B., Pandey, Saurabh, Karamujic, Nermin, Parker, Suzanne, Alexander, Elizabeth, Loutit, Jeffery, Durso, Stephanie, Griffith, David, Lipman, Jeffrey, Wallis, Steven C. and Roberts, Jason A. (2018) Ex vivo characterisation of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam. Antimicrobial Agents and Chemotherapy, 62 10: AAC.01306-18. doi:10.1128/AAC.01306-18

Lefrant, Jean-Yves, Lorne, Emmanuel, Asehnoune, Karim, Ausset, Sylvain, Beaulieu, Pierre, Biais, Matthieu, Brichant, Jean-Francois, Charbit, Beny, Constantin, Jean-Michel, Cuvillon, Philippe, Dadure, Christophe, Dahmani, Souhayl, David, Jean-Stephane, Fuchs-Buder, Thomas, Geeraerts, Thomas, Godier, Anne, Hanouz, Jean-Luc, Joannes-Boyau, Olivier, Kipnis, Eric, Laudenbach, Vincent, Le Guen, Morgan, Legrand, Matthieu, Lescot, Thomas, Marret, Emmanuel, Mongardon, Nicolas, Ouattara, Alexandre, Pierre, Sebastien, Roberts, Jason, Schneider, Antoine, Tourtier, Jean-Pierre, Tran, Laurie, Pirracchio, Romain and Capdevila, Xavier (2018) Determining the editorial policy of Anaesthesia Critical Care and Pain Medicine (ACCPM). Anaesthesia Critical Care & Pain Medicine, 37 4: 299-301. doi:10.1016/j.accpm.2018.07.001

Sime, Fekade B., Stuart, Janine, Butler, Jenie, Starr, Therese, Wallis, Steven C., Pandey, Saurabh, Lipman, Jeffrey and Roberts, Jason A. (2018) A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminemia receiving continuous venovenous hemodiafiltration. International Journal of Antimicrobial Agents, . doi:10.1016/j.ijantimicag.2018.07.008

Dhanani, Jayesh A., Cohen, Jeremy, Parker, Suzanne L., Chan, Hak-Kim, Tang, Patricia, Ahern, Benjamin J., Khan, Adeel, Bhatt, Manoj, Goodman, Steven, Diab, Sara, Chaudhary, Jivesh, Lipman, Jeffrey, Wallis, Steven C., Barnett, Adrian, Chew, Michelle, Fraser, John F. and Roberts, Jason A. (2018) A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models. Intensive Care Medicine Experimental, 6 1: 17. doi:10.1186/s40635-018-0180-7

Jacobs, Alexandra, Taccone, Fabio Silvio, Roberts, Jason A., Jacobs, Frédérique, Wolff, Fleur, Cotton, Frederic, Creteur, Jacques, Vincent, Jean-Louis and Hites, Maya (2018) β-lactam dosage regimens in septic patients with augmented renal clearance. Antimicrobial Agents and Chemotherapy, 62 9: AAC.02534-17. doi:10.1128/AAC.02534-17

Dhanani, Jayesh A., Parker, Suzanne L., Lipman, Jeffrey, Wallis, Steven C., Cohen, Jeremy, Fraser, John, Barnett, Adrian, Chew, Michelle and Roberts, Jason A. (2018) Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions. Journal of Pharmaceutical Analysis, . doi:10.1016/j.jpha.2018.07.003

Heil, Emily L., Nicolau, David P., Farkas, Andras, Roberts, Jason A. and Thom, Kerri A. (2018) Pharmacodynamic target attainment for cefepime, meropenem and piperacillin/tazobactam using a pharmacokinetic/pharmacodynamic-based dosing calculator in critically ill patients. Antimicrobial Agents and Chemotherapy, 62 9: AAC.01008-18. doi:10.1128/AAC.01008-18

Rhodes, Nathaniel J., Liu, Jiajun, Lipman, Jeffrey and Roberts, Jason A. (2018) The authors reply. Critical Care Medicine, 46 7: e725-e726. doi:10.1097/CCM.0000000000003164

Tsai, D., Stewart, P. C., Hewagama, S., Krishnaswamy, S., Wallis, S. C., Lipman, J. and Roberts, J. A. (2018) Optimised dosing of vancomycin in critically ill Indigenous Australian patients with severe sepsis. Anaesthesia and Intensive Care, 46 4: 374-380.

Abdul-Aziz, Mohd H., Driver, Elicia, Lipman, Jeffrey and Roberts, Jason A. (2018) New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimisation rapid microbiological methods. Expert Opinion on Drug Metabolism and Toxicology, 14 7: 1-16. doi:10.1080/17425255.2018.1484452

Parker, Suzanne L, Saxena, Manoj, Gowardman, John, Lipman, Jeffrey, Myburgh, John and Roberts, Jason A. (2018) Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of Critical Care, 47 15-20. doi:10.1016/j.jcrc.2018.05.016

Vickers, Mark L., Dulhunty, Joel M., Ballard, Emma, Chapman, Paul, Muller, Michael, Roberts, Jason A. and Cotta, Menino O. (2018) Risk factors for multidrug-resistant Gram-negative infection in burn patients. ANZ Journal of Surgery, 88 5: 480-485. doi:10.1111/ans.14144

Kanji, Salmaan, Roberts, Jason A., Xie, Jiao, Alobaid, Abdulaziz, Zelenitsky, Sheryl, Hiremath, Swapnil, Zhang, Guijun, Watpool, Irene, Porteous, Rebecca and Patel, Rakesh (2018) Piperacillin population pharmacokinetics in critically ill adults during sustained low-efficiency dialysis. Annals of Pharmacotherapy, 52 10: 106002801877377-973. doi:10.1177/1060028018773771

Bukkems, Laura H., Roger, Claire, Hodiamont, Caspar J., Lefrant, Jean-Yves, Juffermans, Nicole P., Roberts, Jason A. and van Hest, Reinier M. (2018) Predictive performance of a gentamicin population pharmacokinetic model in two Western populations of critically ill patients. International Journal of Antimicrobial Agents, 52 2: 218-225. doi:10.1016/j.ijantimicag.2018.04.016

Gurunathan, Usha, Parker, Suzanne L., Maguire, Richard, Ramdath, Dale, Bijoor, Manu, Wallis, Steven C. and Roberts, Jason A. (2018) Population pharmacokinetics of periarticular ketorolac in adult patients undergoing total hip or total knee replacement surgery. Anesthesia and Analgesia, 1. doi:10.1213/ANE.0000000000003377

Maseda, Emilio, Grau, Santiago, Luque, Sonia, Castillo-Mafla, Maria-Pilar, Suárez-de-la-Rica, Alejandro, Montero-Feijoo, Ana, Salgado, Patricia, Gimenez, Maria-Jose, García-Bernedo, Carlos A., Gilsanz, Fernando and Roberts, Jason A. (2018) Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients. Critical Care, 22 1: 94. doi:10.1186/s13054-018-2019-8

Sime, Fekade B., Stuart, Janine, Butler, Jenie, Starr, Therese, Wallis, Steven C., Pandey, Saurabh, Lipman, Jeffrey and Roberts, Jason A. (2018) Pharmacokinetics of intravenous posaconazole in critically ill patients. Antimicrobial Agents and Chemotherapy, 62 6: e00242-18. doi:10.1128/AAC.00242-18

Heffernan, A. J., Sime, F. B., Lipman, J. and Roberts, J. A. (2018) Individualising therapy to minimize bacterial multidrug resistance. Drugs, 78 6: 621-641. doi:10.1007/s40265-018-0891-9

Tängdén, Thomas, Cojutti, Pier Giorgio, Roberts, Jason A. and Pea, Federico (2018) Valganciclovir pharmacokinetics in patients receiving oral prophylaxis following kidney transplantation and model-based predictions of optimal dosing regimens. Clinical Pharmacokinetics, 57 11: 1-7. doi:10.1007/s40262-018-0638-5

Economou, Caleb J. P., Kielstein, Jan T., Czock, David, Xie, Jiao, Field, Jonathan, Richards, Brent, Tallot, Mandy, Visser, Adam, Koenig, Christina, Hafer, Carsten, Schmidt, Julius J., Lipman, Jeffrey and Roberts, Jason A. (2018) Population pharmacokinetics of vancomycin in critically ill patients receiving prolonged intermittent renal replacement therapy. International Journal of Antimicrobial Agents, 52 2: 151-157. doi:10.1016/j.ijantimicag.2018.03.001

Sinnollareddy, Mahipal G., Roberts, Michael S., Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2018) Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration. The Journal of Antimicrobial Chemotherapy, 73 6: 1647-1650. doi:10.1093/jac/dky057

Cheng, Vesa, Abdul-Aziz, Mohd-Hafiz, Roberts, Jason A. and Shekar, Kiran (2018) Optimising drug dosing in patients receiving extracorporeal membrane oxygenation. Journal of Thoracic Disease, 10 Suppl 5: S629-S641. doi:10.21037/jtd.2017.09.154

Yadav, Rajbharan, Rogers, Kate E., Bergen, Phillip J., Bulitta, Jürgen B., Kirkpatrick, Carl M. J., Wallis, Steven C., Paterson, David L., Nation, Roger L., Lipman, Jeffrey, Roberts, Jason A. and Landersdorfer, Cornelia B. (2018) Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens againstfor patients with altered pharmacokineticsthe hollow-fiber infection model and mechanism-based modeling. Antimicrobial Agents and Chemotherapy, 62 5: e00078-18. doi:10.1128/AAC.00078-18

Stewart, A., Roberts, J. A., Wallis, S. C., Allworth, A. M., Legg, A. and McCarthy, K. L. (2018) Evidence of clinical response and stability of Ceftolozane/Tazobactam used to treat a carbapenem-resistant Pseudomonas Aeruginosa lung abscess on an outpatient antimicrobial program. International Journal of Antimicrobial Agents, 51 6: 941-942. doi:10.1016/j.ijantimicag.2018.02.008

Guerra Valero, Yarmarly C., Wallis, Steven C., Lipman, Jeffrey, Stove, Christophe, Roberts, Jason A. and Parker, Suzanne L. (2018) Clinical application of microsampling versus conventional sampling techniques in the quantitative bioanalysis of antibiotics: a systematic review. Bioanalysis, 10 6: 407-423. doi:10.4155/bio-2017-0269

Minichmayr, Iris K., Roberts, Jason A., Frey, Otto R., Roehr, Anka C., Kloft, Charlotte and Brinkmann, Alexander (2018) Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model. The Journal of Antimicrobial Chemotherapy, 73 5: 1330-1339. doi:10.1093/jac/dkx526

Roberts, Jason A. (2018) Beta-Lactam Therapeutic Drug Monitoring in the Critically Ill Children: Big Solution for Infections in Small People?. Critical Care Medicine, 46 2: 335-337. doi:10.1097/CCM.0000000000002862

Rhodes, Nathaniel J., Liu, Jiajun, O'Donnell, J. Nicholas, Dulhunty, Joel M., Abdul-Aziz, Mohd H., Berko, Patsy Y., Nadler, Barbara, Lipman, Jeffery and Roberts, Jason A. (2018) Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis. Critical Care Medicine, 46 2: 236-243. doi:10.1097/CCM.0000000000002836

Leguelinel-Blache, Géraldine, Nguyen, Tri-Long, Louart, Benjamin, Poujol, Hélène, Lavigne, Jean-Philippe, Roberts, Jason A, Muller, Laurent, Kinowski, Jean-Marie, Roger, Claire and Lefrant, Jean-Yves (2018) Impact of Quality Bundle Enforcement by a Critical Care Pharmacist on Patient Outcome and Costs. Critical Care Medicine, 46 2: 199-207. doi:10.1097/CCM.0000000000002827

Naicker, Saiyuri, Guerra Valero, Yarmarly C., Ordenez Meija, Jenny L., Lipman, Jeffrey, Roberts, Jason A., Wallis, Steven C. and Parker, Suzanne L. (2018) A UHPLC–MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent. Journal of Pharmaceutical and Biomedical Analysis, 148 324-333. doi:10.1016/j.jpba.2017.10.023

Braune, Stephan, König, Christina, Roberts, Jason A., Nierhaus, Axel, Steinmetz, Oliver, Baehr, Michael, Kluge, Stefan and Langebrake, Claudia (2018) Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharmacokinetic study. Critical Care (London, England), 22 1: 1-10. doi:10.1186/s13054-018-1940-1

Heffernan, A., Lipman, J. and Roberts, J. (2018) Re: 'Is a randomized trial of a short course of aminoglycoside added to β-lactam antibiotics for empirical treatment in critically ill patients with sepsis justified?' Pharmacokinetic/pharmacodynamic considerations. Clinical Microbiology and Infection, 24 6: 666-667. doi:10.1016/j.cmi.2017.12.019

Bergen, Phillip J., Bulitta, Jürgen B., Sime, Fekade B., Lipman, Jeffrey, McGregor, Megan J., Millen, Nada, Paterson, David L., Kirkpatrick, Carl M. J., Roberts, Jason A. and Landersdorfer, Cornelia B. (2018) Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli. Diagnostic Microbiology and Infectious Disease, 91 1: 69-76. doi:10.1016/j.diagmicrobio.2017.12.019

Tsai, D., Udy, A. A., Stewart, P. C., Gourley, S., Morick, N. M., Lipman, J. and Roberts, J. A. (2018) Prevalence of augmented renal clearance and performance of glomerular filtration estimates in Indigenous Australian patients requiring intensive care admission. Anaesthesia and Intensive Care, 46 1: 42-50.

König, Christina, Röhr, Anka C., Frey, Otto R., Brinkmann, Alexander, Roberts, Jason A., Wichmann, Dominic, Braune, Stephan, Kluge, Stefan and Nierhaus, Axel (2018) In vitro removal of anti-infective agents by a novel cytokine adsorbent system. International Journal of Artificial Organs, 42 2: 57-64. doi:10.1177/0391398818812601

De Waele, Jan J., Akova, Murat, Antonelli, Massimo, Canton, Rafael, Carlet, Jean, De Backer, Daniel, Dimopoulos, George, Garnacho-Montero, José, Kesecioglu, Jozef, Lipman, Jeffrey, Mer, Mervyn, Paiva, José-Artur, Poljak, Mario, Roberts, Jason A., Rodriguez Bano, Jesus, Timsit, Jean-François, Zahar, Jean-Ralph and Bassetti, Matteo (2017) Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. a position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance. Intensive Care Medicine, 44 2: 189-196. doi:10.1007/s00134-017-5036-1

Dhaese, Sofie A. M., Roberts, Jason A., Carlier, Mieke, Verstraete, Alain G., Stove, Veronique and De Waele, Jan J. (2017) Population pharmacokinetics of piperacillin continuous infusion in critically ill patients. International Journal of Antimicrobial Agents, 51 4: 594-600. doi:10.1016/j.ijantimicag.2017.12.015

Byrne, Catherine J., Parton, Ted, McWhinney, Brett, Fennell, Jerome P., O'Byrne, Philomena, Deasy, Evelyn, Egan, Sean, Enright, Helen, Desmond, Ronan, Ryder, Sheila A., D'Arcy, Deirdre M., McHugh, Johnny and Roberts, Jason A. (2017) Population pharmacokinetics of total and unbound teicoplanin concentrations and dosing simulations in patients with haematological malignancy. The Journal of Antimicrobial Chemotherapy, 73 4: 995-1003. doi:10.1093/jac/dkx473

Abbott, Iain J., Meletiadis, Joseph, Belghanch, Imane, Wijma, Rixt A., Kanioura, Lamprini, Roberts, Jason A., Peleg, Anton Y. and Mouton, Johan W. (2017) Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model. The Journal of Antimicrobial Chemotherapy, 73 3: 709-719. doi:10.1093/jac/dkx441

Parker, Suzanne L., Guerra Valero, Yarmarly C., Lipman, Jeffrey, Weiss, Steven, Smith, Camilla, Russell, Lyndal, Smith, Paul, Roberts, Jason A and Wallis, Steven C (2017) A validated UHPLC-MS/MS method for the measurement of riluzole in plasma and myocardial tissue samples. Biomedical Chromatography, 31 12: e4030. doi:10.1002/bmc.4030

Abdul-Aziz, Mohd H., Lipman, Jeffrey and Roberts, Jason A. (2017) Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections. Critical Care, 21 1: 1-3. doi:10.1186/s13054-017-1871-2

Sime, Fekade Bruck, Hahn, Uwe, Warner, Morgyn S., Tiong, Ing Soo, Roberts, Michael S., Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2017) Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are adequate for the management of febrile neutropenia. Antimicrobial Agents and Chemotherapy, 61 11: e00311-17. doi:10.1128/AAC.00311-17

Global Alliance for Infections in Surgery Working Group and Roberts, Jason (2017) A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway. Surgical Infections, 18 8: 846-853. doi:10.1089/sur.2017.219

Roger, Claire, Roberts, Jason A. and Muller, Laurent (2017) Clinical pharmacokinetics and pharmacodynamics of oxazolidinones. Clinical Pharmacokinetics, 57 5: 1-17. doi:10.1007/s40262-017-0601-x

Sinnah, Fabrice, Shekar, Kiran, Abdul-Aziz, Mohd H, Buscher, Hergen, Diab, Sara D., Fisquet, Stephanie, Fung, Yoke L., McDonald, Charles I., Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan, Xie, Jiao, Fraser, John F., Roberts, Jason A. and ASAP ECMO investigators (2017) Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation. Critical Care and Resuscitation, 19 Suppl 1: 8-14.

Udy, Andrew A, Roberts, Jason A, Lipman, Jeffrey and Blot, Stijn (2017) The effects of major burn related pathophysiological changes on the pharmacokinetics and pharmacodynamics of drug use: An appraisal utilizing antibiotics. Advanced drug delivery reviews, 123 65-74. doi:10.1016/j.addr.2017.09.019

Kumta, Nilesh, Roberts, Jason A., Lipman, Jeffrey and Cotta, Menino Osbert (2017) Antibiotic distribution into cerebrospinal fluid: can dosing safely account for drug and disease factors in the treatment of ventriculostomy-associated infections?. Clinical Pharmacokinetics, 57 4: 439-454. doi:10.1007/s40262-017-0588-3

Sjövall, Fredrik, Alobaid, Abdulaziz S., Wallis, Steven C., Perner, Anders, Lipman, Jeffrey and Roberts, Jason A. (2017) Maximally effective dosing regimens of meropenem in patients with septic shock. The Journal of Antimicrobial Chemotherapy, 73 1: 191-198. doi:10.1093/jac/dkx330

Rello, J., Rouby, J. J., Sole-Lleonart, C., Chastre, J., Blot, S., Luyt, C. E., Riera, J., Vos, M. C., Monsel, A., Dhanani, J. and Roberts, J. A. (2017) Key considerations on nebulization of antimicrobial agents to mechanically ventilated patients. Clinical Microbiology and Infection, 23 9: 640-646. doi:10.1016/j.cmi.2017.03.018

Rello, J., Sole-Lleonart, C., Rouby, J. -J., Chastre, J., Blot, S., Poulakou, G., Luyt, C. -E., Riera, J., Palmer, L. B., Pereira, J. M., Felton, T., Dhanani, J., Bassetti, M., Welte, T. and Roberts, J. A. (2017) Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the European Society of Clinical Microbiology and Infectious Diseases. Clinical Microbiology and Infection, 23 9: 629-639. doi:10.1016/j.cmi.2017.04.011

Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., May, A. K., Sawyer, R. G., Mertz, D., Montravers, P., Kumar, A., Roberts, J. A., Vincent, J. L., Watkins, R. R., Lowman, W., Spellberg, B., Abbott, I. J., Adesunkanmi, A. K., Al-Dahir, S., Al-Hasan, M. N., Agresta, F., Althani, A. A., Ansari, S., Ansumana, R., Augustin, G., Bala, M., Balogh, Z. J., Baraket, O., Bhangu, A., Beltrán, M. A., Bernhard, M., Biffl, W. L., Boermeester, M. A., Brecher, S. M., Cherry-Bukowiec, J. R., Buyne, O. R., Cainzos, M. A., Cairns, K. A., Camacho-Ortiz, A., Chandy, S. J., Che Jusoh, A., Chichom-Mefire, A., Colijn, C., Corcione, F., Cui, Y., Curcio, D., Delibegovic, S., Demetrashvili, Z., De Simone, B., Dhingra, S., Diaz, J. J., Di Carlo, I., Dillip, A., Di Saverio, S., Doyle, M. P., Dorj, G., Dogjani, A., Dupont, H., Eachempati, S. R., Enani, M. A., Egiev, V. N., Elmangory, M. M., Ferrada, P., Fitchett, J. R., Fraga, G. P., Guessennd, N., Giamarellou, H., Ghnnam, W., Gkiokas, G., Goldberg, S. R., Gomes, C. A., Gomi, H., Guzmán-Blanco, M., Haque, M., Hansen, S., Hecker, A., Heizmann, W. R., Herzog, T., Hodonou, A. M., Hong, S. K., Kafka-Ritsch, R., Kaplan, L. J., Kapoor, G., Karamarkovic, A., Kees, M. G., Kenig, J., Kiguba, R., Kim, P. K., Kluger, Y., Khokha, V., Koike, K., Kok, K. Y., Kong, V., Knox, M. C., Inaba, K., Isik, A., Iskandar, K., Ivatury, R. R., Labbate, M., Labricciosa, F. M., Laterre, P. F., Latifi, R., Lee, J. G., Lee, Y. R., Leone, M., Leppaniemi, A., Li, Y., Liang, S. Y., Loho, T., Maegele, M., Malama, S., Marei, H. E., Martin-Loeches, I., Marwah, S., Massele, A., McFarlane, M., Melo, R. B., Negoi, I., Nicolau, D. P., Nord, C. E., Ofori-Asenso, R., Omari, A. H., Ordonez, C. A., Ouadii, M., Pereira Júnior, G. A., Piazza, D., Pupelis, G., Rawson, T. M., Rems, M., Rizoli, S., Rocha, C., Sakakushev, B., Sanchez-Garcia, M., Sato, N., Segovia Lohse, H. A., Sganga, G., Siribumrungwong, B., Shelat, V. G., Soreide, K., Soto, R., Talving, P., Tilsed, J. V., Timsit, J. F., Trueba, G., Trung, N. T., Ulrych, J., van Goor, H., Vereczkei, A., Vohra, R. S., Wani, I., Uhl, W., Xiao, Y., Yuan, K. C., Zachariah, S. K., Zahar, J. R., Zakrison, T. L., Corcione, A., Melotti, R. M., Viscoli, C. and Viale, P. (2017) Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y. World Journal of Emergency Surgery, 12 1: 35. doi:10.1186/s13017-017-0147-0

Xie, Jiao, Roberts, Jason A., Alobaid, Abdulaziz S., Roger, Claire, Wang, Yan, Yang, Qianting, Sun, Jinyao, Dong, Haiyan, Wang, Xue, Xing, Jianfeng, Lipman, Jeffrey and Dong, Yalin (2017) Population pharmacokinetics of tigecycline in critically ill patients with severe infections. Antimicrobial Agents and Chemotherapy, 61 8: e00345-17. doi:10.1128/AAC.00345-17

Roger, Claire, Cotta, Menino O., Muller, Laurent, Wallis, Steven C., Lipman, Jeffrey, Lefrant, Jean-Yves and Roberts, Jason A. (2017) Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients. International Journal of Antimicrobial Agents, 50 2: 227-231. doi:10.1016/j.ijantimicag.2017.03.018

Sartelli, Massimo, Labricciosa, Francesco M., Barbadoro, Pamela, Pagani, Leonardo, Ansaloni, Luca, Brink, Adrian J., Carlet, Jean, Khanna, Ashish, Chichom-Mefire, Alain, Coccolini, Federico, Di Saverio, Salomone, May, Addison K. , Viale, Pierluig, Watkins, Richard R., Scudeller, Luigia, Abbo, Lilian M., Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid K., Al-Dahir, Sara, Al-Hasan, Majdi N., Alis, Halil, Alves, Carlos, Araujo da Silva, Andre .R., Augustin, Goran, Bala, Miklosh, Barie, Philip S., Beltran, Marcelo A., Bhangu, Aneel, Bouchra, Belefquih, Brecher, Stephen M., Cainzos, Miguel A., Camacho-Ortiz, Adrian, Catani, Marco, Chandy, Sujith J., Jusoh, Asri Che, Cherry-Bukowiec, Jill R., Chiara, Osvaldo, Colak, Elif, Cornely, Oliver A., Cui, Yunfeng, Demetrashvili, Zaza, De Simone, Belinda, De Waele, Jan J., Dhingra, Sameer, Di Marzo, Francesco, Dogjani, Agron, Dorj, Gereltuya, Dortet, Laurent, Duane, Therese M., Elmangory, Mutasim M., Enani, Mushira A, Ferrada, Paula, Esteban Foianini, J., Gachabayov, Mahir, Gandhi, Chinmay, Ghnnam, Wagih Mommtaz G, Giamarellou, Helen, Gkiokas, Georgios, Gomi, Harumi, Goranovic, Tatjana, Griffiths, Ewen A. , Guerra Gronerth, Rosio I., Haidamus Monteiro, Julio C., Hardcastle, Timothy C., Hecker, Andreas, Hodonou, Adrien M. , Ioannidis, Orestis, Isik, Arda, Iskandar, Katia A., Kafil, Hossei S., Kanj, Souha S., Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar R., Kenig, Jakub, Kerschaever, Ivan, Khamis, Faryal, Khokha, Vladimir, Kiguba, Ronald, Kim, Hong B., Ko, Wen-Chien, Koike, Kaoru, Kozlovska, Iryna, Kumar, Anand, Lagunes, Leonel, Latifi, Rifat, Lee, Jae G., Lee, Young R., Leppaniemi, Ari, Li, Yousheng , Liang, Stephen Y., Lowman, Warren, Machain, Gustavo M., Maegele, Marc, Major, Piotr, Malama, Sydney, Manzano-Nunez, Ramiro, Marinis, Athanasios, Martinez Casas, Isidro, Marwah, Sanjay, Maseda, Emilio, McFarlane, Michael E., Memish, Ziad, Mertz, Domomol, Mesina, Cristian, Mishra, Shyam K., Moore, Ernest E., Munyika, Akutu, Mylonakis, Eleftherios, Napolitano, Lena, Negoi, Ionut, Nestorovic, Milica D., Nicolau, David P., Omari, Abdelkarim H., Ordonez, Carlos A., Paiva, Jose-Artur., Pant, Narayan D., Parreira, Jose G., Pedziwiatr, Michal, Pereira, Bruno M., Ponce-de-Leon, Alfredo, Poulakou, Garyphallia, Preller, Jacobus, Pulcini, Celine, Pupelis, Guntars, Quiodettis, Martha, Rawson, Timothy M., Reis, Tarcisio, Rems, Miran, Rizoli, Sandro, Roberts, Jason, Pereira, Nuno Rocha, Rodriguez-Bano, Jesus, Sakakushev, Boris, Sanders, James, Santos, Natalie, Sato, Norio, Sawyer, Robert G., Scarpelini, Sandro, Scoccia, Loredana , Shafiq, Nusrat, Shelat, Vishalkumar, Sifri, Costi D., Siribumrungwong, Boonying , Soreide, Kjetil, Soto, Rodolfo, de Souza, Hamilton P., Talving, Peep, Trung, Ngo Tat, Tessier, Jeffrey M., Tumbarellom, Mario, Ulrych, Jan, Uranues, Selman, Van Goor, Harry, Vereczkei, Andras, Wagenlehner, Florian, Xiao, Yonghong, Yuan, Kuo-Ching, Wechsler-Fordos, Agnes, Zahar, Jean-Ralph, Zakrison, Tanya L., Zuckerbraun, Brian, Zuidema, Wietse P. and Catena, Fausto (2017) The Global Alliance for Infections in Surgery: Defining a model for antimicrobial stewardship-results from an international cross-sectional survey. World Journal of Emergency Surgery, 12 1: 34. doi:10.1186/s13017-017-0145-2

Bruggink, Leesa D., Moselen, Jean M., Roberts, Jason A. and Marshall, John A. (2017) Evolutionary changes in the capsid P2 region of Australian strains of the norovirus GII.Pe_GII.4. Journal of Medical Microbiology, 66 7: 1014-1022. doi:10.1099/jmm.0.000531

Sulaiman, Helmi, Abdul-Aziz, Mohd H. and Roberts, Jason A. (2017) Pharmacokinetic/pharmacodynamics-optimized antimicrobial therapy in patients with hospital-acquired pneumonia/ventilator-associated pneumonia. Seminars in Respiratory and Critical Care Medicine, 38 3: 271-286. doi:10.1055/s-0037-1602716

Parker, Suzanne L., Valero, Yarmarly C. Guerra, Mejia, Jenny L. Ordonez, Roger, Claire, Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2017) An LC-MS/MS method to determine vancomycin in plasma (total and unbound), urine and renal replacement therapy effluent. Bioanalysis, 9 12: 911-924. doi:10.4155/bio-2017-0019

Byrne, Catherine J., Roberts, Jason A., McWhinney, Brett, Fennell, Jerome P., O'Byrne, Philomena, Deasy, Evelyn, Egan, Sean, Desmond, Ronan, Enright, Helen, Ryder, Sheila A., D'Arcy, Deirdre M. and McHugh, Johnny (2017) Variability in trough total and unbound teicoplanin concentrations and achievement of therapeutic drug monitoring targets in adult patients with hematological malignancy. Antimicrobial Agents and Chemotherapy, 61 6: e02466-16. doi:10.1128/AAC.02466-16

Naik, B. I., Roger, C., Ikeda, K., Todorovic, M. S., Wallis, S. C., Lipman, J. and Roberts, J. A. (2017) Comparative total and unbound pharmacokinetics of cefazolin administered by bolus versus continuous infusion in patients undergoing major surgery: a randomized controlled trial. British Journal of Anaesthesia, 118 6: 876-882. doi:10.1093/bja/aex026

Konig, Christina, Braune, Stephan, Roberts, Jason A., Nierhaus, Axel, Steinmetz, Oliver M., Baehr, Michael, Frey, Otto R., Langebrake, Claudia and Kluge, Stefan (2017) Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis. Journal of Antimicrobial Chemotherapy, 72 5: 1433-1440. doi:10.1093/jac/dkw592

Economou, Caleb J. P., Wong, Gloria, McWhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2017) Impact of β-lactam antibiotic therapeutic drug monitoring on dose adjustments in critically ill patients undergoing continuous renal replacement therapy. International Journal of Antimicrobial Agents, 49 5: 589-594. doi:10.1016/j.ijantimicag.2017.01.009

Bergen, Phillip J., Bulitta, Jurgen B., Kirkpatrick, Carl M. J., Rogers, Kate E., McGregor, Megan J., Wallis, Steven C., Paterson, David L., Nation, Roger L., Lipman, Jeffrey, Roberts, Jason A. and Landersdorfer, Cornelia B. (2017) Substantial impact of altered pharmacokinetics in critically Ill patients on the antibacterial effects of meropenem evaluated via the dynamic hollow-fiber infection model. Antimicrobial Agents and Chemotherapy, 61 5: e02642-16. doi:10.1128/AAC.02642-16

Sole-Lleonart, Candela, Rouby, Jean-Jacques, Blot, Stijn, Poulakou, Garyfallia, Chastre, Jean, Palmer, Lucy B., Bassetti, Matteo, Luyt, Charles-Edouard, Pereira, Jose M., Riera, Jordi, Felton, Tim, Dhanani, Jayesh, Welte, Tobias, Garcia-Alamino, Jose M., Roberts, Jason A. and Rello, Jordi (2017) Nebulization of antiinfective agents in invasively mechanically ventilated adults: a systematic review and meta-analysis. Anesthesiology, 126 5: 890-908. doi:10.1097/ALN.0000000000001570

Roberts, Jason A., Lefrant, Jean-Yves and Lipman, Jeffrey (2017) What’s new in pharmacokinetics of antimicrobials in AKI and RRT?. Intensive Care Medicine, 43 6: 1-3. doi:10.1007/s00134-017-4789-x

Coulter, Sonali, Roberts, Jason A., Hajkowicz, Krispin and Halton, Kate (2017) The use of bloodstream infection mortality to measure the impact of antimicrobial stewardship interventions: assessing the evidence. Infectious Disease Reports, 9 1: 8-12. doi:10.4081/idr.2017.6849

Udy, Andrew A., Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Starr, Therese, Paul, Sanjoy K. and Lipman, Jeffrey (2017) Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested cohort study of the BLING-II randomised, placebo-controlled, clinical trial. International Journal of Antimicrobial Agents, 49 5: 624-630. doi:10.1016/j.ijantimicag.2016.12.022

Byrne, C. J., Roberts, J. A., McWhinney, B., Ryder, S. A., Fennell, J. P., O'Byrne, P., Deasy, E., Egan, S., Desmond, R., Enright, H., D'Arcy, D. M. and McHugh, J. (2017) Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy. Clinical Microbiology and Infection, 23 9: 674.e7-674.e13. doi:10.1016/j.cmi.2017.02.032

Alobaid, Abdulaziz S., Wallis, Steven C., Jarrett, Paul, Starr, Therese, Stuart, Janine, Lassig-Smith, Melissa, Mejia, Jenny Lisette Ordóñez, Roberts, Michael S., Roger, Claire, Udy, Andrew A., Lipman, Jeffrey and Roberts, Jason A. (2017) Population pharmacokinetics of piperacillin in nonobese, obese, and morbidly obese critically ill patients. Antimicrobial Agents and Chemotherapy, 61 3: e01276-16. doi:10.1128/AAC.01276-16

Paruk, Fathima, Sime, Fekade B., Lipman, Jeffrey and Roberts, Jason A. (2017) Dosing antibiotic prophylaxis during cardiopulmonary bypass—a higher level of complexity? A structured review. International Journal of Antimicrobial Agents, 49 4: 395-402. doi:10.1016/j.ijantimicag.2016.12.014

Silbert, Benjamin I., Ho, Kwok M., Lipman, Jeffrey, Roberts, Jason A., Corcoran, Tomas B., Morgan, David J., Pavey, Warren, Mas, Emilie, Barden, Anne E. and Mori, Trevor A. (2017) Does furosemide increase oxidative stress in acute kidney injury?. Antioxidants & Redox Signaling, 26 5: 221-226. doi:10.1089/ars.2016.6845

Roberts, Jason A., Kumar, Anand and Lipman, Jeffrey (2017) Right dose, right now: customized drug dosing in the critically ill. Critical Care Medicine, 45 2: 331-336. doi:10.1097/CCM.0000000000002210

Sime, Fekade Bruck, Johnson, Adam, Whalley, Sarah, Santoyo-Castelazo, Anahi, Montgomery, A. Bruce, Walters, Kathie Ann, Lipman, Jeffrey, Hope, William W. and Roberts, Jason A. (2017) Pharmacodynamics of aerosolized fosfomycin and amikacin against resistant clinical isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a hollow-fiber infection model: experimental basis for combination therapy. Antimicrobial Agents and Chemotherapy, 61 1: e01763-16. doi:10.1128/AAC.01763-16

Udy, Andrew A., Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Starr, Therese, Dunlop, Rachel, Deans, Renae, Roberts, Jason A., Senthuran, Siva, Boots, Robert, Bisht, Kavita, Bulmer, Andrew C. and Lipman, Jeffrey (2017) Augmented renal clearance in traumatic brain injury: a single-center observational study of atrial natriuretic peptide, cardiac output, and creatinine clearance. Journal of Neurotrauma, 34 1: 137-144. doi:10.1089/neu.2015.4328

Roger, C., Wallis, S.C., Muller, L., Saissi, G., Lipman, J., Bruggemann, R.J., Lefrant, J.-Y. and Roberts, J.A. (2016) Caspofungin Population Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-Venous Haemofiltration or Haemodiafiltration. Clinical Pharmacokinetics, 56 9: 1-12. doi:10.1007/s40262-016-0495-z

Abdul-Aziz, Mohd. H., Lipman, Jeffrey and Roberts, Jason A. (2016) Antibiotic dosing for multidrug-resistant pathogen pneumonia. Current Opinion in Infectious Diseases, 30 2: 231-239. doi:10.1097/QCO.0000000000000348

Tsai, Danny, Stewart, Penelope, Goud, Rajendra, Gourley, Stephen, Hewagama, Saliya, Krishnaswamy, Sushena, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2016) Pharmacokinetics of piperacillin in critically ill Australian Indigenous patients with severe sepsis. Antimicrobial Agents and Chemotherapy, 60 12: 7402-7406. doi:10.1128/AAC.01657-16

Tsai, Danny, Stewart, Penelope, Goud, Rajendra, Gourley, Stephen, Hewagama, Saliya, Krishnaswamy, Sushena, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2016) Total and unbound ceftriaxone pharmacokinetics in critically ill Australian Indigenous patients with severe sepsis. International Journal of Antimicrobial Agents, 48 6: 748-752. doi:10.1016/j.ijantimicag.2016.09.021

Farkas, Andras, Daroczi, Gergely, Villasurda, Phillip, Dolton, Michael, Nakagaki, Midori and Roberts, Jason A. (2016) Comparative evaluation of the predictive performances of three different structural population pharmacokinetic models to predict future voriconazole concentrations. Antimicrobial Agents and Chemotherapy, 60 11: 6806-6812. doi:10.1128/AAC.00970-16

Alobaid, Abdulaziz S., Wallis, Steven C., Jarrett, Paul, Starr, Therese, Stuart, Janine, Lassig-Smith, Melissa, Mejia, Jenny Lisette Ordóñez, Roberts, Michael S., Sinnollareddy, Mahipal G., Roger, Claire, Lipman, Jeffrey and Roberts, Jason A. (2016) Effect of obesity on the population pharmacokinetics of fluconazole in critically Ill patients. Antimicrobial Agents and Chemotherapy, 60 11: 6550-6557. doi:10.1128/AAC.01088-16

Veringa, Anette, Sturkenboom, Marieke G. G., Dekkers, Bart G. J., Koster, Remco A., Roberts, Jason A., Peloquin, Charles A., Touw, Daan J. and Alffenaar, Jan-Willem C. (2016) LC-MS/MS for therapeutic drug monitoring of anti-infective drugs. Trends in Analytical Chemistry, 84 34-40. doi:10.1016/j.trac.2015.11.026

Tsai, Danny, Stewart, Penelope, Goud, Rajendra, Gourley, Stephen, Hewagama, Saliya, Krishnaswamy, Sushena, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2016) Optimising meropenem dosing in critically ill Australian Indigenous patients with severe sepsis. International Journal of Antimicrobial Agents, 48 5: 542-546. doi:10.1016/j.ijantimicag.2016.08.015

Parker, Suzanne L., Guerra Valero, Yarmarly C., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2016) Effect of time on recovery of plasma microsamples for the quantitative determination of vancomycin. Bioanalysis, 8 21: 2235-2242. doi:10.4155/bio-2016-0159

Dhanani, Jayesh, Fraser, John F., Chan, Hak-Kim, Rello, Jordi, Cohen, Jeremy and Roberts, Jason A. (2016) Fundamentals of aerosol therapy in critical care. Critical Care, 20 1: 269. doi:10.1186/s13054-016-1448-5

Garcia-De-Lorenzo, A., Luque, S., Grau, S., Agrifoglio, A., Cachafeiro, L., Herrero, E., Asensio, M. J., Sanchez, S. M. and Roberts, J. A. (2016) Comparative population plasma and tissue pharmacokinetics of micafungin in critically ill patients with severe burn injuries and patients with complicated intra-abdominal infection. Antimicrobial Agents and Chemotherapy, 60 10: 5914-5921. doi:10.1128/AAC.00727-16

Zelenitsky, S. A., Lawson, C., Calic, D., Ariano, R. E., Roberts, J. A., Lipman, J. and Zhanel, G. G. (2016) Integrated pharmacokinetic-pharmacodynamic modelling to evaluate antimicrobial prophylaxis in abdominal surgery. Journal of Antimicrobial Chemotherapy, 71 10: 2902-2908. doi:10.1093/jac/dkw247

Tabah, Alexis, Lipman, Jeffrey and Roberts, Jason A. (2016) Are new gentamicin dosing guidelines suitable for achieving target concentrations in patients with sepsis and septic shock?. Anaesthesia, Critical Care and Pain Medicine, 35 5: 311-312. doi:10.1016/j.accpm.2016.08.002

Bandeshe, Hiran, Boots, Rob, Dulhunty, Joel, Dunlop, Rachael, Holley, Anthony, Jarrett, Paul, Gomersall, Charles D., Lipman, Jeff, Lo, Thomas, O'Donoghue, Steven, Paratz, Jenny, Paterson, David, Roberts, Jason A., Starr, Therese, Stephens, Di, Stuart, Janine, Thomas, Jane, Udy, Andrew and White, Hayden (2016) Is inhaled prophylactic heparin useful for prevention and management of pneumonia in ventilated ICU patients?. Journal of Critical Care, 35 231-239. doi:10.1016/j.jcrc.2016.06.022

Silbert, Benjamin I., Ho, Kwok M., Lipman, Jeffrey, Roberts, Jason A., Corcoran, Tomas B., Morgan, David J., Pavey, Warren, Mas, Emilie, Barden, Anne E. and Mori, Trevor A. (2016) Determinants of urinary output response to IV furosemide in acute kidney injury: a pharmacokinetic/pharmacodynamic study. Critical Care Medicine, 44 10: e923-e929. doi:10.1097/CCM.0000000000001823

Osthoff, Michael, Siegemund, Martin, Balestra, Gianmarco, Abdul-Aziz, Mohd H. and Roberts, Jason A. (2016) Prolonged administration of beta-lactam antibiotics - a comprehensive review and critical appraisal. Swiss Medical Weekly, 146 w14368-w14368. doi:10.4414/smw.2016.14368

Abdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016) Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 10: 1535-1545. doi:10.1007/s00134-015-4188-0

Roberts, Jason A., Abdul-Aziz, Mohd-Hafiz, Davis, Joshua S., Dulhunty, Joel M., Cotta, Menino O., Myburgh, John, Bellomo, Rinaldo and Lipman, Jeffrey (2016) Continuous versus intermittent β-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials. American Journal of Respiratory and Critical Care Medicine, 194 6: 681-691. doi:10.1164/rccm.201601-0024OC

Mcdonald, Craig, Cotta, Menino O., Little, Peter J., Mcwhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2016) Is high-dose beta-lactam therapy associated with excessive drug toxicity in critically ill patients?. Minerva Anestesiologica, 82 9: 957-965.

Dorofaeff, Tavey, Bandini, Rossella M., Lipman, Jeffrey, Ballot, Daynia E., Roberts, Jason A. and Parker, Suzanne L. (2016) Uncertainty in antibiotic dosing in critically ill neonate and pediatric patients: can microsampling provide the answers?. Clinical Therapeutics, 38 9: 1961-1975. doi:10.1016/j.clinthera.2016.07.093

Bergen, Phillip J., Bulitta, Jurgen B., Kirkpatrick, Carl M. J., Rogers, Kate E., McGregor, Megan J., Wallis, Steven C., Paterson, David L., Lipman, Jeffrey, Roberts, Jason A. and Landersdorfer, Cornelia B. (2016) Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling. Journal of Antimicrobial Chemotherapy, 71 9: 2509-2520. doi:10.1093/jac/dkw153

Hanrahan, Timothy P., Lipman, Jeffrey and Roberts, Jason A. (2016) Antibiotic dosing in obesity: a BIG challenge. Critical Care, 20 240: 240. doi:10.1186/s13054-016-1426-y

Cristallini, Stefano, Hites, Maya, Kabtouri, Hakim, Roberts, Jason A., Beumier, Marjorie, Cotton, Frederic, Lipman, Jeffrey, Jacobs, Frederique, Vincent, Jean-Louis, Creteur, Jacques and Taccone, Fabio Silvio (2016) New regimen for continuous infusion of vancomycin in critically ill patients. Antimicrobial Agents and Chemotherapy, 60 8: 4750-4756. doi:10.1128/AAC.00330-16

Sole-Lleonart, Candela, Rouby, Jean-Jacques, Chastre, Jean, Poulakou, Garyfallia, Palmer, Lucy B., Blot, Stijn, Felton, Tim, Bassetti, Matteo, Luyt, Charles-Eduard, Pereira, Joao Manuel, Riera, Jordi, Welte, Tobias, Roberts, Jason A. and Rello, Jordi (2016) Intratracheal administration of antimicrobial agents in mechanically ventilated adults: an international survey on delivery practices and safety. Respiratory Care, 61 8: 1008-1014. doi:10.4187/respcare.04519

Roger, Claire, Wallis, Steven C., Muller, Laurent, Saissi, Gilbert, Lipman, Jeffrey, Lefrant, Jean-Yves and Roberts, Jason A. (2016) Influence of renal replacement modalities on amikacin population pharmacokinetics in critically ill patients on continuous renal replacement therapy. Antimicrobial Agents and Chemotherapy, 60 8: 4901-4909. doi:10.1128/AAC.00828-16

Alobaid, Abdulaziz S., Wallis, Steven C., Jarrett, Paul, Starr, Therese, Stuart, Janine, Lassig-Smith, Melissa, Ordonez Mejia, Jenny Lisette, Roberts, Michael S., Lipman, Jeffrey and Roberts, Jason A. (2016) Effect of obesity on the population pharmacokinetics of meropenem in critically ill patients. Antimicrobial Agents and Chemotherapy, 60 8: 4577-4584. doi:10.1128/AAC.00531-16

Sartelli, Massimo, Weber, Dieter G., Ruppe, Etienne, Bassetti, Matteo, Wright, Brian J., Ansaloni, Luca, Catena, Fausto, Coccolini, Federico, Abu-Zidan, Fikri M., Coimbra, Raul, Moore, Ernest E., Moore, Frederick A., Maier, Ronald V., De Waele, Jan J., Kirkpatrick, Andrew W., Griffiths, Ewen A., Eckmann, Christian, Brink, Adrian J., Mazuski, John E., May, Addison K., Sawyer, Rob G., Mertz, Dominik, Montravers, Philippe, Kumar, Anand, Roberts, Jason A., Vincent, Jean-Louis, Watkins, Richard R., Lowman, Warren, Spellberg, Brad, Abbott, Iain J., Adesunkanmi, Abdulrashid Kayode, Al-Dahir, Sara, Al-Hasan, Majdi N., Agresta, Ferdinando, Althani, Asma A., Ansari, Shamshul, Ansumana, Rashid, Augustin, Goran, Bala, Miklosh, Balogh, Zsolt J., Baraket, Oussama, Bhangu, Aneel, Beltran, Marcelo A., Bernhard, Michael, Biffl, Walter L., Boermeester, Marja A., Brecher, Stephen M., Cherry-Bukowiec, Jill R., Buyne, Otmar R., Cainzos, Miguel A., Cairns, Kelly A., Camacho-Ortiz, Adrian, Chandy, Sujith J., Jusoh, Asri Che, Chichom-Mefire, Alain, Colijn, Caroline, Corcione, Francesco, Cui, Yunfeng, Curcio, Daniel, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Dhingra, Sameer, Diaz, Jose J., Di Carlo, Isidoro, Dillip, Angel, Di Saverio, Salomone, Doyle, Michael P., Dorj, Gereltuya, Dogjani, Agron, Dupont, Herve, Eachempati, Soumitra R., Enani, Mushira Abdulaziz, Egiev, Valery N., Elmangory, Mutasim M., Ferrada, Paula, Fitchett, Joseph R., Fraga, Gustavo P., Guessennd, Nathalie, Giamarellou, Helen, Ghnnam, Wagih, Gkiokas, George, Goldberg, Staphanie R., Gomes, Carlos Augusto, Gomi, Harumi, Guzman-Blanco, Manuel, Haque, Mainul, Hansen, Sonja, Hecker, Andreas, Heizmann, Wolfgang R., Herzog, Torsten, Hodonou, Adrien Montcho, Hong, Suk-Kyung, Kafka-Ritsch, Reinhold, Kaplan, Lewis J., Kapoor, Garima, Karamarkovic, Aleksandar, Kees, Martin G., Kenig, Jakub, Kiguba, Ronald, Kim, Peter K., Kluger, Yoram, Khokha, Vladimir, Koike, Kaoru, Kok, Kenneth Y. Y., Kong, Victory, Knox, Matthew C., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao R., Labbate, Maurizio, Labricciosa, Francesco M., Laterre, Pierre-Francois, Latifi, Rifat, Lee, Jae Gil, Lee, Young Ran, Leone, Marc, Leppaniemi, Ari, Li, Yousheng, Liang, Stephen Y., Loho, Tonny, Maegele, Marc, Malama, Sydney, Marei, Hany E., Martin-Loeches, Ignacio, Marwah, Sanjay, Massele, Amos, McFarlane, Michael, Melo, Renato Bessa, Negoi, Ionut, Nicolau, David P., Nord, Carl Erik, Ofori-Asenso, Richard, Omari, AbdelKarim H., Ordonez, Carlos A., Ouadii, Mouaqit, Pereira Junior, Gerson Alves, Piazza, Diego, Pupelis, Guntars, Rawson, Timothy Miles, Rems, Miran, Rizoli, Sandro, Rocha, Claudio, Sakakhushev, Boris, Sanchez-Garcia, Miguel, Sato, Norio, Lohse, Helmut A. Segovia, Sganga, Gabriele, Siribumrungwong, Boonying, Shelat, Vishal G., Soreide, Kjetil, Soto, Rodolfo, Talving, Peep, Tilsed, Jonathan V., Timsit, Jean-Francois, Trueba, Gabriel, Trung, Ngo Tat, Ulrych, Jan, van Goor, Harry, Vereczkei, Andras, Vohra, Ravinder S., Wani, Imtiaz, Uhl, Waldemar, Xiao, Yonghong, Yuan, Kuo-Ching, Zachariah, Sanoop K., Zahar, Jean-Ralph, Zakrison, Tanya L., Corcione, Antonio, Melotti, Rita M., Viscoli, Claudio and Viale, Perluigi (2016) Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World Journal of Emergency Surgery, 11 1: 33. doi:10.1186/s13017-016-0089-y

Ranganathan, Dwarakanathan, Naicker, Saiyuri, Wallis, Steven C., Lipman, Jeffrey, Ratanjee, Sharad K. and Roberts, Jason A. (2016) Stability of antibiotics for intraperitoneal administration in extraneal 7.5% icodextrin peritoneal dialysis bags (stab study). Peritoneal Dialysis International, 36 4: 421-426. doi:10.3747/pdi.2015.00062

Roberts, Darren M., Ranganathan, Dwarakanathan, Wallis, Steven C., Varghese, Julie M., Kark, Adrian, Lipman, Jeffrey and Roberts, Jason A. (2016) Pharmacokinetics of intraperitoneal cefalothin and cefazolin in patients being treated for peritoneal dialysis-associated peritonitis. Peritoneal Dialysis International, 36 4: 415-420. doi:10.3747/pdi.2015.00008

Cotta, Menino O., Dulhunty, Joel M., Roberts, Jason A., Myburgh, John and Lipman, Jeffrey (2016) Should β-lactam antibiotics be administered by continuous infusion in critically ill patients? A survey of Australia and New Zealand intensive care unit doctors and pharmacists. International Journal of Antimicrobial Agents, 47 6: 436-438. doi:10.1016/j.ijantimicag.2016.02.017

Roger, Claire, Wallis, Steven C., Louart, Benjamin, Lefrant, Jean-Yves, Lipman, Jeffrey, Muller, Laurent and Roberts, Jason A. (2016) Comparison of equal doses of continuous venovenous haemofiltration and haemodiafiltration on ciprofloxacin population pharmacokinetics in critically ill patients. Journal of Antimicrobial Chemotherapy, 71 6: 1643-1650. doi:10.1093/jac/dkw043

Parker, Suzanne L., Guerra Valero, Yarmarly C., Roberts, Darren M., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2016) Determination of cefalothin and cefazolin in human plasma, urine and peritoneal dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans. Biomedical Chromatography, 30 6: 872-879. doi:10.1002/bmc.3622

Cotta, Menino Osbert, Roberts, Jason A. and Lipman, Jeffrey (2016) We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how?. Critical Care, 20 1: . doi:10.1186/s13054-016-1348-8

Calandra, Thierry, Roberts, Jason A., Antonelli, Massimo, Bassetti, Matteo and Vincent, Jean-Louis (2016) Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy. Critical Care, 20 1: . doi:10.1186/s13054-016-1313-6

Vincent, Jean-Louis, Bassetti, Matteo, Francois, Bruno, Karam, George, Chastre, Jean, Torres, Antoni, Roberts, Jason A., Taccone, Fabio S., Rello, Jordi, Calandra, Thierry, De Backer, Daniel, Welte, Tobias and Antonelli, Massimo (2016) Advances in antibiotic therapy in the critically ill. Critical Care, 20 1: . doi:10.1186/s13054-016-1285-6

Parker, Suzanne L., Dorofaeff, Tavey, Lipman, Jeffrey, Ballot, Daynia E., Bandini, Rossella M., Wallis, Steven C. and Roberts, Jason A. (2016) Is there a role for microsampling in antibiotic pharmacokinetic studies?. Expert Opinion on Drug Metabolism and Toxicology, 12 6: 601-614. doi:10.1080/17425255.2016.1178238

Jager, Nynke G., van Hest, Reinier M., Lipman, Jeffrey, Taccone, Fabio S. and Roberts, Jason A. (2016) Therapeutic drug monitoring of anti-infective agents in critically ill patients. Expert Review of Clinical Pharmacology, 9 7: 961-979. doi:10.1586/17512433.2016.1172209

Tabah, Alexis, Cotta, Menino Osbert, Garnacho-Montero, Jose, Schouten, Jeroen, Roberts, Jason A., Lipman, Jeffrey, Tacey, Mark, Timsit, Jean-Francois, Leone, Marc, Zahar, Jean Ralph and De Waele, Jan J. (2016) A systematic review of the definitions, determinants, and clinical outcomes of antimicrobial de-escalation in the Intensive Care Unit. Clinical Infectious Diseases, 62 8: 1009-1017. doi:10.1093/cid/civ1199

Denny, Kerina J., Cotta, Menino O., Parker, Suzanne L., Roberts, Jason A. and Lipman, Jeffrey (2016) The use and risks of antibiotics in critically ill patients. Expert Opinion on Drug Safety, 15 5: 667-678. doi:10.1517/14740338.2016.1164690

Alobaid, Abdulaziz S., Hites, Maya, Lipman, Jeffrey, Taccone, Fabio Silvio and Roberts, Jason A. (2016) Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: a structured review. International Journal of Antimicrobial Agents, 47 4: 259-268. doi:10.1016/j.ijantimicag.2016.01.009

Bellapart, Judith, Roberts, Jason Alexander, Appadurai, Vinesh, Wallis, Steven C., Nunez-Nunez, Maria and Boots, Robert James (2016) Pharmacokinetics of a novel dosing regimen of oral melatonin in critically ill patients. Clinical Chemistry and Laboratory Medicine, 54 3: 467-472. doi:10.1515/cclm-2015-0323

Alobaid, Abdulaziz S., Brinkmann, Alexander, Frey, Otto R., Roehr, Anka C., Luque, Sonia, Grau, Santiago, Wong, Gloria, Abdul-Aziz, Mohd-Hafiz, Roberts, Michael S., Lipman, Jeffrey and Roberts, Jason A. (2016) What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?. Journal of Antimicrobial Chemotherapy, 71 3: 696-702. doi:10.1093/jac/dkv412

Roberts, Jason A., Choi, Gordon Y. S., Joynt, Gavin M., Paul, Sanjoy K., Deans, Renae, Peake, Sandra, Cole, Louise, Stephens, Dianne, Bellomo, Rinaldo, Turnidge, John, Wallis, Steven C., Roberts, Michael S., Roberts, Darren M., Lassig-Smith, Melissa, Starr, Therese and Lipman, Jeffrey (2016) SaMpling antibiotics in renal replacement therapy (SMARRT): an observational pharmacokinetic study in critically ill patients. Bmc Infectious Diseases, 16 1: 103.1-103.8. doi:10.1186/s12879-016-1421-6

Roberts, Jason A., Cotta, Menino Osbert, Cojutti, Piergiorgio, Lugano, Manuela, Rocca, Giorgio D. and Pea, Federico (2016) Does critical illness change levofloxacin pharmacokinetics?. Antimicrobial Agents and Chemotherapy, 60 3: 1459-1463. doi:10.1128/AAC.02610-15

Delgado-Valverde, Mercedes, Torres, Eva, Valiente-Mendez, Adoracion, Almirante, Benito, Gomez-Zorrilla, Silvia, Borrell, Nuria, Corzo, Juan E., Gurgui, Mercedes, Almela, Manuel, Garcia-Alvarez, Lara, Fontecoba-Sanchez, Maria Crus, Martinez-Martinez, Luis, Canton, Rafael, Praena, Julia, Causse, Manuel, Gutierrez-Gutierrez, Belen, Roberts, Jason A., Farkas, Andras, Pascual, Alvaro, Rodriguez-Bano, Jesus, de Cueto, Marina, Planes Reig, Ana Maria, Quintano, Fe Tubau, Pena, Carmen, Galan Otalora, M. Elvira, Alegria, Carlos Ruiz de, Morosini, M. Isabel, Lepe, Jose Antonio, Cisneros, Jose Miguel, Morey, Shawna and Abdul-Aziz, Mohd-Hafiz (2016) Impact of the MIC of piperacillin/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the Bacteraemia-MIC project. Journal of Antimicrobial Chemotherapy, 71 2: 521-530. doi:10.1093/jac/dkv362

Roger, C., Muller, L., Wallis, S. C., Louart, B., Saissi, G., Lipman, J., Lefrant, J. Y. and Roberts, J. A. (2016) Population pharmacokinetics of linezolid in critically ill patients on renal replacement therapy: comparison of equal doses in continuous venovenous haemofiltration and continuous venovenous haemodiafiltration. Journal of Antimicrobial Chemotherapy, 71 2: 464-470. doi:10.1093/jac/dkv349

Sinnollareddy, Mahipal G., Roberts, Michael S., Lipman, Jeffrey, Lassig-Smith, Melissa, Starr, Therese, Robertson, Thomas, Peake, Sandra L. and Roberts, Jason A. (2016) In vivo microdialysis to determine subcutaneous interstitial fluid penetration and pharmacokinetics of fluconazole in intensive care unit patients with sepsis. Antimicrobial Agents and Chemotherapy, 60 2: 827-832. doi:10.1128/AAC.02461-15

Sime, Fekade Bruck and Roberts, Jason A. (2016) Antibiotic dosing in critically ill patients receiving renal replacement therapy. Expert Review of Clinical Pharmacology, 9 4: 497-499. doi:10.1586/17512433.2016.1133290

Abdul-Aziz, Mohd H., Abd Rahman, Azrin N., Mat-Nor, Mohd-Basri, Sulaiman, Helmi, Wallis, Steven C., Lipman, Jeffrey, Roberts, Jason A. and Staatz, Christine E. (2016) Population pharmacokinetics of doripenem in critically ill patients with sepsis in a Malaysian intensive care unit. Antimicrobial Agents and Chemotherapy, 60 1: 206-214. doi:10.1128/AAC.01543-15

Roger, Claire, Nucci, Bastian, Louart, Benjamin, Friggeri, Arnaud, Knani, Haroun, Evrard, Alexandre, Lavigne, Jean-Philippe, Allaouchiche, Bernard, Lefrant, Jean-Yves, Roberts, Jason A. and Muller, Laurent (2016) Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis. Journal of Antimicrobial Chemotherapy, 71 1: 208-212. doi:10.1093/jac/dkv291

Abdul-Aziz, Mohd H., Lipman, Jeffrey, Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Dulhunty, Joel, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C., Roberts, Jason A., Paul, Sanjoy, Ribas, Antonio Margarit, De Crop, Luc, Spapen, Herbert, Wauters, Joost, Dugernier, Thierry, Jorens, Philippe, Dapper, Ilse, De Backer, Daniel, Taccone, Fabio S., Ruano, Laura, Afonso, Elsa, Alvarez-Lerma, Francisco, Gracia-Arnillas, Maria Pilar, Fernandez, Francisco, Feijoo, Neus, Bardolet, Neus, Rovira, Assumpta, Garro, Pau, Colon, Diana, Castillo, Carlos, Fernado, Juan, Lopez, Maria Jesus, Fernandez, Jose Luis, Arribas, Ana Maria, Teja, Jose Luis, Ots, Elsa, Montejo, Juan Carlos, Catalan, Marcedes, Prieto, Isidro, Gonzalo, Gloria, Galvan, Beatriz, Blasco, Miguel Ange, Meyer, Estibaliz, Nogal, Frutos Del, Vidaur, Loreto, Sebastian, Rosa, Garde, Pila Marco, Velasco, Maria del Mar Martin, Crespo, Rafael Zaragoza, Esperatti, Mariano, Torres, Antoni, Baldesi, Olivier, Dupont, Herve, Mahjoub, Yazine, Lasocki, Sigismond, Constantin, Jean Michel, Payen, Jean Francois, Albanese, Jacques, Malledant, Yannick, Pottecher, Julien, Lefrant, Jean-Yves, Jaber,Samir, Joannes-Boyau, Olivier, Orban,Christophe, Ostermann, Marlies, McKenzie, Catherine, Berry, Willaim, Smith, John, Lei, Katie, Rubulotta, Francesca, Gordon, Anthony, Brett, Stephen, Stotz, Martin, Templeton, Maie, Ebm, Claudia, Moran, Carl, Pettila, Ville, Xristodoulou, Aglaia, Theodorou, Vassiliki, Kouliatsis, Georgios, Sertaridou, Eleni, Anthopoulos, Georgios, Choutas, George, Rantis, Thanos, Karatzas, Stylianos, Balla, Margarita, Papanikolaou, Metaxia, Myrianthefs, Pavlos, Gavala, Alexandra, Fildisis, Georgios, Koutsoukou, Antonia, Kyriakopoulou, Magdalini, Petrochilou, Kalomoira, Kompoti, Maria, Michalia, Martha, Clouva-Molyvdas, Fillis-Maria, Gkiokas, Georgios, Nikolakopoulos, Fotios, Psychogiou, Vasiliki, Malliotakis, Polychronis, Akoumianaki, Evangelia, Lilitsis, Emmanouil, Koulouras, Vassilios, Nakos, George, Kalogirou, Mihalis, Komnos, Apostolos, Zafeiridis, Tilemachos, Chaintoutis, Christos, Arvaniti, Kostoula, Matamis, Dimitrios, Kydona, Christina, Gritsi-Gerogianni, Nikoleta, Giasnetsova, Tatiana, Giannakou, Maria, Soultati, Ioanna, Chytas, Ilias, Antoniadou, Eleni, Antipa, Elli, Lathyris, Dimitrios, Koukoubani,Triantafyllia, Paraforou, Theoniki, Spiropoulou, Kyriaki, Bekos, Vasileios, Spring, Anna, Kalatzi, Theodora, Nikolaou, Hara, Laskou, Maria, Strouvalis, Ioannis, Aloizos, Stavros, Kapogiannis, Spyridon, Soldatou, Ourania, Adembri, Chiara, Villa, Gianluca, Giarratano, Antonio, Raineri, Santi Maurizio, Cortegiani, Andrea, Montalto, Francesca, Strano, Maria Teresa, Ranieri, V. Marco, Sandroni, Claudio, De Pascale, Gennaro, Molin, Alexandre, Pelosi, Paolo, Montagnani, Luca, Urbino, Rosario, Mastromauro, Ilaria, De Rosa, Francesco G., Cardoso, Teresa, Afonso, Susana, Goncalves-Pereira, Joao, Baptista, Joao Pedro and Ozveren, Arife (2016) Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DA. Journal of Antimicrobial Chemotherapy, 71 1: 196-207. doi:10.1093/jac/dkv288

Saxena, Manoj K., Taylor, Colman, Billot, Laurent, Bompoint, Severine, Gowardman, John, Roberts, Jason A., Lipman, Jeffery and Myburgh, John (2015) The effect of paracetamol on core body temperature in acute traumatic brain injury: a randomised, controlled clinical trial. PloS One, 10 12: e0144740. doi:10.1371/journal.pone.0144740

Shekar, Kiran, Roberts, Jason A., Barnett, Adrian G., Diab, Sara, Wallis, Steven C., Fung, Yoke L. and Fraser, John F. (2015) Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models. Critical Care, 19 1: 1-11. doi:10.1186/s13054-015-1151-y

Cotta, M. O., Roberts, J. A. and Lipman, J. (2015) Antibiotic dose optimization in critically ill patients / Optimización de la dosis de antibióticos en pacientes críticamente enfermos. Medicina Intensiva (English Edition), 39 9: 563-572. doi:10.1016/j.medine.2015.07.001

Huttner, Angela, Harbarth, Stephan, Hope, William W., Lipman, Jeffrey and Roberts, Jason A. (2015) Therapeutic drug monitoring of the beta-lactam antibiotics: what is the evidence and which patients should we be using it for?. Journal of Antimicrobial Chemotherapy, 70 12: 3178-3183. doi:10.1093/jac/dkv201

Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A.R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Starr, Therese, Paul, Sanjoy K., Lipman, Jeffrey, Bellomo, Rinaldo, Peck, Leah, Young, Helen, Boschert , Catherine, Fletcher, Jason, Smith, Julie, Nand, Kiran, Sara, Treena, Harney, Amy, Rodgers, Helen, Van Haren, Frank, Clarke, Sally, Durham, David, Hannan, Catherine, Matheson, Elisha, Schwartz, Kate, Thomas, Karen, Bone, Allison, Cattigan, Claire, Elderkin, Tania, Salerno, Tania, Cameron, Robert, Ellis, Katrina, Hatter, Sheridan, Davis, Joshua, Sanap, Milind, Soar, Natalie, Wood, Josette, Chan, Karen, Heffernan, Aaron, Lai, Nai An, Moss, Catherine, Sheehy, Kate, Duroux, Maree, Ratcliffe, Megan, Shone, Samantha, Warhurst, Timothy, Dunlop, Rachel, Roberts, Jason, Stuart, Janine, Udy, Andrew, Cooper, David, McAllister, Rick, Cheng, Andrew, Inskip, Deborah, Miller, Jennene, Reynolds, Claire, Rudham, Sam, Baker, Stuart, Hepburn, Kristy, Roberts, Brigit, Woods, Paul, Chatterjee, Indranil, Smith, Judy, Cullen, Martin, Kong, Jing, Nayyar, Vineet, Leung, Patricia, Whitehead, Christina, Gilder, Eileen, McCarthy, Lianne, McGuiness, Shay, Parke, Rachael, Benefield, Kirsten, Chen, Yan, McArthur, Colin, Newby, Lynette, Henderson, Seton, Mehrtens, Jan, Noble, Sascha, Chadwick, Lesley, Freebain, Ross, Hogan, Chantal, Kazemi, Alex, Rust, Laura, Song, Rima, Tilsley, Anna, Williams, Anthony, Andrews, Lynn, Dinsdale, Richard, Hunt, Anna, Hurford, Sally, Mackle, Diane, Ongley, Jessica, Young, Paul, Durning, John, Frengley, Robert, La Pine, Mary, McCracken, Geoff, Sharma, Swarna Baskar, Kollef, Marin, Turnidge, John and Paul, Sanjoy (2015) A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis. American Journal of Respiratory and Critical Care Medicine, 192 11: 1298-1305. doi:10.1164/rccm.201505-0857OC

Flores, Orlando, Stockton, Kellie, Roberts, Jason A., Muller, Michael J. and Paratz, Jennifer D. (2015) The efficacy and safety of adrenergic blockade post burn injury: a systematic review and meta-analysis. Journal of Trauma and Acute Care Surgery, 80 1: 146-155. doi:10.1097/TA.0000000000000887

Parker, Suzanne L., Lipman, Jeffrey, Dimopoulos, George, Roberts, Jason A. and Wallis, Steven C. (2015) A validated method for the quantification of fosfomycin on dried plasma spots by HPLC-MS/MS: application to a pilot pharmacokinetic study in humans. Journal of Pharmaceutical and Biomedical Analysis, 115 509-514. doi:10.1016/j.jpba.2015.07.013

Grau, S., Luque, S., Campillo, N., Samso, E., Rodriguez, U., Garcia-Bernedo, C.A., Salas, E., Sharma, R., Hope, W.W. and Roberts, J.A. (2015) Plasma and peritoneal fluid population pharmacokinetics of micafungin in post-surgical patients with severe peritonitis. Journal of Antimicrobial Chemotherapy, 70 10: 2854-2861. doi:10.1093/jac/dkv173

Parker, Suzanne L., Frantzeskaki, Frantzeska, Wallis, Steven C., Diakaki, Chryssa, Giamarellou, Helen, Koulenti, Despoina, Karaiskos, Ilias, Lipman, Jeffrey, Dimopoulos, George and Roberts, Jason A. (2015) Population pharmacokinetics of fosfomycin in critically ill patients. Antimicrobial Agents and Chemotherapy, 59 10: 6471-6476. doi:10.1128/AAC.01321-15

Sime, F. B., Roberts, M. S. and Roberts, J. A. (2015) Optimization of dosing regimens and dosing in special populations. Clinical Microbiology and Infection, 21 10: 886-893. doi:10.1016/j.cmi.2015.05.002

Iyer, Kartik K., Roberts, James A., Hellstrom-Westas, Lena, Wikstrom, Sverre, Hansen Pupp, Ingrid, Ley, David, Breakspear, Michael and Vanhatalo, Sampsa (2015) Early detection of preterm intraventricular hemorrhage from clinical electroencephalography. Critical Care Medicine, 43 10: 2219-2227. doi:10.1097/CCM.0000000000001190

Parker, Suzanne L., Roberts, Jason A., Lipman, Jeffrey and Wallis, Steven C. (2015) Quantitative bioanalytical validation of fosfomycin in human whole blood with volumetric absorptive microsampling. Bioanalysis, 7 19: 2585-2595. doi:10.4155/bio.15.173

Sime, Fekade B., Udy, Andrew A. and Roberts, Jason A. (2015) Augmented renal clearance in critically ill patients: etiology, definition and implications for beta-lactam dose optimization. Current Opinion in Pharmacology, 24 1-6. doi:10.1016/j.coph.2015.06.002

Tsai, Danny, Lipman, Jeffrey and Roberts, Jason A. (2015) Pharmacokinetic/pharmacodynamic considerations for the optimization of antimicrobial delivery in the critically ill. Current Opinion in Critical Care, 21 5: 412-420. doi:10.1097/MCC.0000000000000229

Parker, Suzanne L., Sime, Fekade B. and Roberts, Jason A. (2015) Optimizing dosing of antibiotics in critically ill patients. Current Opinion in Infectious Diseases, 28 6: 497-504. doi:10.1097/QCO.0000000000000206

Cairns, Kelly A., Roberts, Jason A., Cotta, Menino O. and Cheng, Allen C. (2015) Antimicrobial stewardship in Australian hospitals and other settings. Infectious Diseases and Therapy, 4 Supp.1: 27-38. doi:10.1007/s40121-015-0083-9

Roberts, Jason A., Taccone, Fabio Silvio. and Lipman, Jeffrey. (2015) Understanding PK/PD. Intensive Care Medicine, 42 11: 1797-1800. doi:10.1007/s00134-015-4032-6

Parker, Suzanne L., Adnan, Syamhanin, Meija, Jenny L. Ordonez, Paterson, David L., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2015) An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine. Bioanalysis, 7 18: 2311-2319. doi:10.4155/bio.15.143

Sime, Fekade Bruck., Roberts, Michael S., Tiong, Ing Soo., Gardner, Julia H., Lehman, Sheila., Peake, Sandra L., Hahn, Uwe., Warner, Morgyn S. and Roberts, Jason A. (2015) Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies. Antimicrobial Agents and Chemotherapy, 59 9: 5463-5469. doi:10.1128/AAC.00389-15

Hanrahan, T. P., Kotapati, C., Roberts, M. J., Rowland, J., Lipman, J., Roberts, J. A. and Udy, A. (2015) Factors associated with vancomycin nephrotoxicity in the critically ill. Anaesthesia and Intensive Care, 43 5: 594-599.

Hanrahan, Timothy, Whitehouse, Tony, Lipman, Jeffrey and Roberts, Jason A. (2015) Vancomycin-associated nephrotoxicity: a meta-analysis of administration by continuous versus intermittent infusion. International Journal of Antimicrobial Agents, 46 3: 249-253. doi:10.1016/j.ijantimicag.2015.04.013

Tabah, Alexis, De Waele, Jan, Lipman, Jeffrey, Zahar, Jean Ralph, Cotta, Menino Osbert, Barton, Greg, Timsit, Jean-Francois and Roberts, Jason A. (2015) The ADMIN-ICU survey: a survey on antimicrobial dosing and monitoring in ICUs. Journal of Antimicrobial Chemotherapy, 70 9: 2671-2677. doi:10.1093/jac/dkv165

Lipman, Jeffrey and Roberts, Jason (2015) Does appropriate antibiotic therapy mean only adequate spectrum and timing?. Critical Care Medicine, 43 8: 1773-1774. doi:10.1097/CCM.0000000000001060

Jamal, Janattul-Ain, Udy, Andrew A., Wallis, Steven C., Ranganathan, Dwarakanathan, McWhinney, Brett C., Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2015) Can we use an ex vivo continuous hemofiltration model to describe the adsorption and elimination of meropenem and piperacillin?. International Journal of Artificial Organs, 38 8: 419-424. doi:10.5301/ijao.5000422

Carlier, Mieke, Roberts, Jason A., Stove, Veronique, Verstraete, Alain G., Lipman, Jeffrey and De Waele, Jan J. (2015) A simulation study reveals lack of pharmacokinetic/pharmacodynamic target attainment in de-escalated antibiotic therapy in critically ill patients. Antimicrobial Agents and Chemotherapy, 59 8: 4689-4694. doi:10.1128/AAC.00409-15

Levy, Avram, Roberts, Jason, Lang, Jurissa, Tempone, Simone, Kesson, Alison, Dofai, Alfred, Daley, Andrew J., Thorley, Bruce and Speers, David J. (2015) Enterovirus D68 disease and molecular epidemiology in Australia. Journal of Clinical Virology, 69 117-121. doi:10.1016/j.jcv.2015.06.079

Coulter, Sonali, Merollini, Katharina, Roberts, Jason A., Graves, Nicholas and Halton, Kate (2015) The need for cost-effectiveness analyses of antimicrobial stewardship programmes: a structured review. International Journal of Antimicrobial Agents, 46 2: 140-149. doi:10.1016/j.ijantimicag.2015.04.007

Carlier, Mieke, Stove, Veronique, Wallis, Steven C., De Waele, Jan J., Verstraete, Alain G., Lipman, Jeffrey and Roberts, Jason A. (2015) Assays for therapeutic drug monitoring of β-lactam antibiotics: a structured review. International Journal of Antimicrobial Agents, 46 4: 367-375. doi:10.1016/j.ijantimicag.2015.06.016

Jamal, Janattul-Ain, Roberts, Darren M., Udy, Andrew A., Mat-Nor, Mohd-Basri, Mohamad-Nor, Fariz-Safhan, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2015) Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: a randomised controll edtrial of continuous infusion versus intermittent bolus administration. International Journal of Antimicrobial Agents, 46 1: 39-44. doi:10.1016/j.ijantimicag.2015.02.014

Sinnollareddy, Mahipal G., Roberts, Michael S., Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2015) Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: use of microdialysis. International Journal of Antimicrobial Agents, 46 1: 121-124. doi:10.1016/j.ijantimicag.2015.02.017

Roger, Claire, Nucci, Bastian, Molinari, Nicolas, Bastide, Sophie, Saissi, Gilbert, Pradel, Gael, Barbar, Saber, Aubert, Clement, Lloret, Sophie, Elotmani, Loubna, Polge, Anne, Lefrant, Jean-Yves, Roberts, Jason A and Muller, Laurent (2015) Standard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations. International Journal of Antimicrobial Agents, 46 1: 21-27. doi:10.1016/j.ijantimicag.2015.02.009

Lopez-Garcia, Belen, Luque, Sonia, Roberts, Jason A. and Grau, Santiago (2015) Pharmacokinetics and preliminary safety ofhigh dose linezolid for the treatment of Gram-positive bacterial infections. Journal of Infection, 71 5: 604-607. doi:10.1016/j.jinf.2015.06.007

D'Agostino, Carly, Rhodes, Nathaniel J., Skoglund, Erik, Roberts, Jason A. and Scheetz, Marc H. (2015) Microbiologic clearance following transition from standard infusion piperacillin-tazobactam to extended-infusion for persistent Gram-negative bacteremia and possible endocarditis: a case report and review of the literature. Journal of Infection and Chemotherapy, 21 10: 742-746. doi:10.1016/j.jiac.2015.05.010

Roberts, Jason A., Hobday, Linda K., Ibrahim, Aishah, Aitkin, Thomas and Thorley, Bruce R. (2015) Australian National Enterovirus Reference Laboratory annual report, 2013. Communicable Diseases Intelligence Quarterly Report, 39 2: E208-E216.

Brink, A. J., Richards, G. A., Lautenbach, E. E. G., Rapeport, N., Schillack, V., van Niekerk, L., Lipman, J. and Roberts, J. A. (2015) Albumin concentration significantly impacts on free teicoplanin plasma concentrations in non-critically ill patients with chronic bone sepsis. International Journal of Antimicrobial Agents, 45 6: 647-651. doi:10.1016/j.ijantimicag.2015.01.015

Sime, Fekade B., Roberts, Michael S., Tiong, Ing S., Gardner, Julia H., Lehman, Sheila, Peake, Sandra L., Hahn, Uwe, Warner, Morgyn S. and Roberts, Jason A. (2015) Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial. Journal of Antimicrobial Chemotherapy, 70 8: 2369-2375. doi:10.1093/jac/dkv123

De Waele, J. J., Lipman, J., Akova, M., Bassetti, M. , Dimopoulos, G., Kaukonen, M., Koulenti, D., Martin, C., Montravers, P. , Rello, J. , Rhodes, A. , Udy, A. A. , Starr, T. , Wallis, S. C. and Roberts, J. A. (2015) Erratum to: Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Intensive Care Medicine, 41 5: 969-969. doi:10.1007/s00134-015-3772-7

Hanrahan, Timothy P., Harlow, Georgina, Dulhunty, Joel M., Lipman, Jeffrey, Whitehouse, Tony and Roberts, Jason A. (2015) Vancomycin-associated nephrotoxicity: unintentional consequences of a loading dose? Reply. Critical Care Medicine, 43 5: E154-E155. doi:10.1097/CCM.0000000000000952

Jamal, Janattul-Ain, Mueller, Bruce A., Choi, Gordon Y. S., Lipman, Jeffrey and Roberts, Jason A. (2015) How can we ensure effective antibiotic dosing in critically ill patients receiving different types of renal replacement therapy?. Diagnostic Microbiology and Infectious Disease, 82 1: 92-103. doi:10.1016/j.diagmicrobio.2015.01.013

Shekar, Kiran, Roberts, Jason A, Mcdonald, Charles I, Ghassabian, Sussan, Anstey, Chris, Wallis, Steven C, Mullany, Daniel V, Fung, Yoke L and Fraser, John F (2015) Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: Results from an ex vivo study. Critical Care, 19 164: . doi:10.1186/s13054-015-0891-z

Roberts, Darren M., Liu, Xin, Roberts, Jason A., Nair, Priya, Cole, Louise, Roberts, Michael S., Lipman, Jeffrey and Bellomo, Rinaldo (2015) A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics. Critical Care (London, England), 19 1-9. doi:10.1186/s13054-015-0818-8

Roberts, Darren M, Liu, Xin, Roberts, Jason A, Nair, Priya, Cole, Louise, Roberts, Michael S, Lipman, Jeffrey, Bellomo, Rinaldo and RENAL Replacement Therapy Study Investigators (2015) A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics. Critical Care, 19 84: . doi:10.1186/s13054-015-0818-8

Wong G., Farkas A., Sussman R., Daroczi G., Hope W.W., Lipman J. and Roberts J.A. (2015) Comparison of the accuracy and precision of pharmacokinetic equations to predict free meropenem concentrations in critically ill patients. Antimicrobial Agents and Chemotherapy, 59 3: 1411-1417. doi:10.1128/AAC.04001-14

Donadello, Katia, Antonucci, Elio, Cristallini, Stefano, Roberts, Jason A., Beumier, Marjorie, Scolletta, Sabino, Jacobs, Frederique, Rondelet, Benoit, de Backer, Daniel, Vincent, Jean-Louis and Taccone, Fabio Silvio (2015) β-Lactam pharmacokinetics during extracorporeal membrane oxygenation therapy: A case-control study. International Journal of Antimicrobial Agents, 45 3: 278-282. doi:10.1016/j.ijantimicag.2014.11.005

Barnett, Adrian G., Herbert, Danielle L., Campbell, Megan, Daly, Naomi, Roberts, Jason A., Mudge, Alison and Graves, Nicholas (2015) Streamlined research funding using short proposals and accelerated peer review: An observational study. BMC Health Services Research, 15 1: . doi:10.1186/s12913-015-0721-7

Parker S.L., Lipman J., Roberts J.A. and Wallis S.C. (2015) A simple LC-MS/MS method using HILIC chromatography for the determination of fosfomycin in plasma and urine: Application to a pilot pharmacokinetic study in humans. Journal of Pharmaceutical and Biomedical Analysis, 105 39-45. doi:10.1016/j.jpba.2014.11.042

Sinnollareddy, Mahipal G., Roberts, Jason A., Lipman, Jeffrey, Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C. and Dimopoulos, George (2015) Pharmacokinetic variability and exposures of fluconazole, anidulafungin, and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study. Critical Care, 19 33: 1-7. doi:10.1186/s13054-015-0758-3

Sinnollareddy, Mahipal G., Roberts, Michael S., Lipman, Jeffrey, Robertson, Thomas A., Peake, Sandra L. and Roberts, Jason A. (2015) Pharmacokinetics of fluconazole in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration. International Journal of Antimicrobial Agents, 45 2: 192-195. doi:10.1016/j.ijantimicag.2014.08.013

Varghese J.M., Jarrett P., Wallis S.C., Boots R.J., Kirkpatrick C.M.J., Lipman J. and Roberts J.A. (2015) Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?. Journal of Antimicrobial Chemotherapy, 70 2: 528-533. doi:10.1093/jac/dku413

Abdul-Aziz, Mohd H., Lipman, Jeffrey, Mouton, Johan W., Hope, William W. and Roberts, Jason A. (2015) Applying Pharmacokinetic/Pharmacodynamic Principles in Critically Ill Patients: Optimizing Efficacy and Reducing Resistance Development. Seminars in Respiratory and Critical Care Medicine, 36 1: 136-153. doi:10.1055/s-0034-1398490

Kanji S., Hayes M., Ling A., Shamseer L., Chant C., Edwards D.J., Edwards S., Ensom M.H.H., Foster D.R., Hardy B., Kiser T.H., La Porte C., Roberts J.A., Shulman R., Walker S., Zelenitsky S. and Moher D. (2015) Reporting Guidelines for Clinical Pharmacokinetic Studies: The ClinPK Statement. Clinical Pharmacokinetics, 54 7: 783-795. doi:10.1007/s40262-015-0236-8

Udy, Andrew A., Lipman, Jeffrey, Jarrett, Paul, Klein, Kerenaftali, Wallis, Steven C., Patel, Kashyap, Kirkpatrick, Carl M. J., Kruger, Peter S., Paterson, David L., Roberts, Michael S. and Roberts, Jason A. (2015) Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?. Critical Care, 19 28: 1-9. doi:10.1186/s13054-015-0750-y

Harris, Patrick N. A., Peleg, Anton Y., Iredell, Jon, Ingram, Paul R., Miyakis, Spiros, Stewardson, Andrew J., Rogers, Benjamin A., McBryde, Emma S., Roberts, Jason A., Lipman, Jeff, Athan, Eugene, Paul, Sanjoy K., Baker, Peter, Harris-Brown, Tiffany and Paterson, David L. (2015) Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial. Trials, 16 1: 24.1-24.8. doi:10.1186/s13063-014-0541-9

Cotta, Menino Osbert, Gowen, Belinda, Truloff, Natasha, Bursle, Evan, Mcwhinney, Brett, Ungerer, Jacobus P. J., Roberts, Jason A. and Lipman, Jeffrey (2015) Even high-dose extended infusions may not yield desired concentrations of beta-lactams: the value of therapeutic drug monitoring. Infectious Diseases, 47 10: 739-742. doi:10.3109/23744235.2015.1021831

De Waele, J.J., Lipman, J., Carlier, M. and Roberts, J.A. (2015) Subtleties in practical application of prolonged infusion of β-lactam antibiotics. International Journal of Antimicrobial Agents, 45 5: 461-463. doi:10.1016/j.ijantimicag.2015.01.007

Carlier, Mieke, Taccone, Fabio S, Beumier, Majorie, Seyler, Lucie, Cotton, Frederic, Jacobs, Grederique and Roberts, Jason A (2015) Population pharmacokinetics and dosing simulations of cefepime in septic shock patients receiving continuous renal replacement therapy. International Journal of Antimicrobial Agents, 46 4: 413-419. doi:10.1016/j.ijantimicag.2015.05.020

Roehr, Anka C., Frey, Otto R., Koeberer, Andreas, Fuchs, Thomas, Roberts, Jason A. and Brinkmann, Alexander (2015) Anti-infective drugs during continuous hemodialysis - using the bench to learn what to do at the bedside. International Journal of Artificial Organs, 38 1: 17-22. doi:10.5301/ijao.5000377

Jamal, Janattul-Ain, Mat-Nor, Mohd-Basri, Mohamad-Nor, Fariz-Safhan, Udy, Andrew A., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2015) Pharmacokinetics of meropenem in critically ill patients receiving continuous venovenous haemofiltration: A randomised controlled trial of continuous infusion versus intermittent bolus administration. International Journal of Antimicrobial Agents, 45 1: 41-45. doi:10.1016/j.ijantimicag.2014.09.009

Orchard, Gregory R., Paratz, Jennifer D., Blot, Stijn and Roberts, Jason A. (2014) Risk factors in hospitalized patients with burn injuries for developing heterotopic ossification—a retrospective analysis. Journal of Burn Care and Research, 36 4: 465-470. doi:10.1097/BCR.0000000000000123

Shekar, Kiran, Fraser, John F., Taccone, Fabio Silvio, Welch, Susan, Wallis, Steven C., Mullany, Daniel V., Lipman, Jeffrey and Roberts, Jason A. (2014) The combined effects of extracorporeal membrane oxygenation and renal replacement therapy on meropenem pharmacokinetics: a matched cohort study. Critical Care, 18 6: 1-9. doi:10.1186/s13054-014-0565-2

Baptista, Joao P., Roberts, Jason A., Sousa, Eduardo, Freitas, Ricardo, Deveza, Nuno and Pimentel, Jorge (2014) Decreasing the time to achieve therapeutic vancomycin concentrations in critically ill patients: Developing and testing of a dosing nomogram. Critical Care, 18 654: 1-9. doi:10.1186/s13054-014-0654-2

Chau, M. M., Kong, D. C. M., van Hal, S. J., Urbancic, K., Trubiano, J. A., Cassumbhoy, M., Wilkes, J., Cooper, C. M., Roberts, J. A., Marriott, D. J. E. and Worth, L. J. (2014) Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy, 2014. Internal Medicine Journal, 44 12: 1364-1388. doi:10.1111/imj.12600

De Waele, J., Carlier, M., Hoste, E., Depuydt, P., Decruyenaere, J., Wallis, S. C., Lipman, J. and Roberts, J. A. (2014) Extended versus bolus infusion of meropenem and piperacillin: a pharmacolcinetic analysis. Minerva Anestesiologica, 80 12: 1302-1309.

Hanrahan, Timothy P., Harlow, Georgina, Hutchinson, James, Dulhunty, Joel M., Lipman, Jeffrey, Whitehouse, Tony and Roberts, Jason A. (2014) Vancomycin-associated nephrotoxicity in the critically ill: a retrospective multivariate regression analysis. Critical Care Medicine, 42 12: 2527-2536. doi:10.1097/CCM.0000000000000514

Roberts, Jason A. (2014) Therapeutic drug monitoring of antibiotics – author's reply. Lancet Infectious Diseases, 14 12: 1181-1181. doi:10.1016/S1473-3099(14)71007-2

Udy, Andrew A., Jarrett, Paul, Stuart, Janine, Lassig-Smith, Melissa, Starr, Therese, Dunlop, Rachel, Wallis, Steven C., Roberts, Jason A. and Lipman, Jeffrey (2014) Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds. Critical Care, 18 657: 1-9. doi:10.1186/s13054-014-0657-z

Wong, Gloria, Sime, Fekade Bruck, Lipman, Jeffrey and Roberts, Jason A. (2014) How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?. BMC Infectious Diseases, 14 288: 1-11. doi:10.1186/1471-2334-14-288

Donadello, Katia, Roberts, Jason A., Cristallini, Stefano, Beumier, Marjorie, Shekar, Kiran, Jacobs, Frederique, Belhaj, Asmae, Vincent, Jean-Louis, de Backer, Daniel and Taccone, Fabio Silvio (2014) Vancomycin population pharmacokinetics during extracorporeal membrane oxygenation therapy: a matched cohort study. Critical Care, 18 632: 1-10. doi:10.1186/s13054-014-0632-8

Tsai, Danny, Jamal, Janattul-Ain, Davis, Joshua S., Lipman, Jeffrey and Roberts, Jason A. (2014) Interethnic differences in pharmacokinetics of antibacterials. Clinical Pharmacokinetics, 54 3: 243-260. doi:10.1007/s40262-014-0209-3

Roberts, Jason A. and Fraser, John F. (2014) Meeting the challenges of advanced drug delivery in critical illness. Advanced Drug Delivery Reviews, 77 1-2. doi:10.1016/j.addr.2014.11.002

Adnan, S., Ratnam, S., Kumar, S., Paterson, D., Lipman, J., Roberts, J. and Udy, A. A. (2014) Select critically ill patients at risk of augmented renal clearance: experience in a Malaysian intensive care unit. Anaesthesia And Intensive Care, 42 6: 715-722.

Carlier, Mieke, Noe, Michael, Roberts, Jason A., Stove, Veronique, Verstraete, Alain G., Lipman, Jeffrey and De Waele, Jan J. (2014) Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic exposures. Journal of Antimicrobial Chemotherapy, 69 10: 2797-2803. doi:10.1093/jac/dku195

Abdul-Aziz, Mohd H., McDonald, Craig, McWhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014) Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU. Annals of Pharmacotherapy, 48 10: 1380-1384. doi:10.1177/1060028014540610

Roberts, Jason A., Paul, Sanjoy K., Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C. and Lipman, Jeffrey (2014) Impact of loading doses on the time to adequate predicted beta-lactam concentrations in prolonged and continuous infusion dosing schemes: reply to Rhodes et al. Clinical Infectious Diseases, 59 6: 907-908. doi:10.1093/cid/ciu403

Luque, S., Grau, S., Alvarez-Lerma, F., Ferrandez, O., Campillo, N., Horcajada, J.P., Basas, M., Lipman, J. and Roberts, J.A. (2014) Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections. International Journal of Antimicrobial Agents, 44 5: 409-415. doi:10.1016/j.ijantimicag.2014.07.001

Felton, T. W., Hope, W. W. and Roberts, J. A. (2014) How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?. Diagnostic Microbiology and Infectious Disease, 79 4: 441-447. doi:10.1016/j.diagmicrobio.2014.04.007

De Rosa, Francesco G. and Roberts, Jason A. (2014) Amikacin dosing in the ICU: we now know more, but still not enough .... Intensive Care Medicine, 40 7: 1033-1035. doi:10.1007/s00134-014-3308-6

Jamal, Janattul-Ain, Udy, Andrew A., Lipman, Jeffrey and Roberts, Jason A. (2014) The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens. Critical Care Medicine, 42 7: 1640-1650. doi:10.1097/CCM.0000000000000317

Nunez-Nunez, Maria, Bellapart, Judith, O'Donoghue, Steven, McWhinney, Brett, Ungerer, Jacobus P.J., Lipman, Jeffrey and Roberts, Jason A. (2014) Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?. International Journal of Antimicrobial Agents, 43 6: 571-572. doi:10.1016/j.ijantimicag.2014.03.001

Nunez-Nunez, Maria, Bellapart, Judith, O’Donoghue, Steven, McWhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014) Variable ganciclovir concentrations in a critically ill patient receiving continuous renal replacement therapy and plasma exchange?. International journal of antimicrobial agents, 43 6: 572-573. doi:10.1016/j.ijantimicag.2014.03.001

Sime, Fekade Bruck, Roberts, Michael S., Roberts, Jason A. and Robertson, Thomas A. (2014) Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies. Journal of Chromatography B, 960 134-144. doi:10.1016/j.jchromb.2014.04.029

Maseda, Emilio, Grau, Santiago, Villagran, Maria-Jose, Hernandez-Gancedo, Carmen, Lopez-Tofino, Araceli, Roberts, Jason A., Aguilar, Lorenzo, Luque, Sonia, Sevillano, David, Gimenez, Maria-Jose and Gilsanz, Fernando (2014) Micafungin pharmacokinetic/pharmacodynamic adequacy for the treatment of invasive candidiasis in critically ill patients on continuous venovenous haemofiltration. Journal of Antimicrobial Chemotherapy, 69 6: 1624-1632. doi:10.1093/jac/dku013

Blot, Stijn, Koulenti, Despoina, Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2014) Does contemporary vancomycin dosing achieve therapeutic targets in a heterogeneous clinical cohort of critically ill patients? Data from the multinational DALI study. Critical Care, 18 3: 1-11. doi:10.1186/cc13874

Roberts, Jason A., Udy, Andrew A., Jarrett, Paul, Wallis, Steven C., Hope, William W., Sharma, Raman, Kirkpatrick, Carl M. J., Kruger, Peter S., Roberts, Michael S. and Lipman, Jeffrey (2014) Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients. Journal of Antimicrobial Chemotherapy, 70 5: 1495-1502. doi:10.1093/jac/dku564

Blot,Stijn, Lipman, Jeffrey, Roberts, Darren M. and Roberts, Jason A (2014) The influence of acute kidney injury on antimicrobial dosing in critically ill patients: Are dose reductions always necessary?. Diagnostic Microbiology and Infectious Disease, 79 1: 77-84. doi:10.1016/j.diagmicrobio.2014.01.015

Wong, Gloria, Brinkman, Alexander, Benefield, Russell J., Carlier, Mieke, De Waele, Jan J., Helali, Najoua, Frey, Otto, Harbarth, Stephan, Huttner, Angela, McWhinney, Brett, Misset, Benoit, Pea, Federico, Preisenberger, Judit, Roberts, Michael S., Robertson, Thomas A., Roehr, Anka, Sime, Fekade Bruck, Taccone, Fabio Silvio, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2014) An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units. Journal of Antimicrobial Chemotherapy, 69 5: 1416-1423. doi:10.1093/jac/dkt523

Roberts, Jason A., Paul, Sanjoy K., Akova, Murat, Bassetti, Matteo, De Waele, Jan J., Dimopoulos, George, Kaukonen, Kirsi-Maija, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven C. and Lipman, Jeffrey (2014) DALI: defining antibiotic levels in intensive care unit patients. Are current beta-lactam antibiotic doses sufficient for critically ill patients?. Clinical Infectious Diseases, 58 8: 1072-1083. doi:10.1093/cid/ciu027

Smits, Anne, Roberts, Jason A., Vella-Brincat, Jane W. A. and Allegaert, Karel (2014) Cefazolin plasma protein binding in different human populations: More than cefazolin-albumin interaction. International Journal of Antimicrobial Agents, 43 2: 199-200. doi:10.1016/j.ijantimicag.2013.10.008

Varghese, Julie M., Jarrett, Paul, Boots, Robert J., Kirkpatrick, Carl M. J., Lipman, Jeffrey and Roberts, Jason A. (2014) Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration. International Journal of Antimicrobial Agents, 43 4: 343-348. doi:10.1016/j.ijantimicag.2014.01.009

Holstege, Gert, Beers, Caroline M. and Subramanian, Hari H. (2014) Preface. Progress in Brain Research, 209 xi-xii. doi:10.1016/B978-0-444-63488-7.10000-X

Jamal, Janattul-Ain, Mat-Nor, Mohd-Basri, Mohamad-Nor, Fariz-Safhan, Udy, Andrew A., Lipman, Jeffrey and Roberts, Jason A. (2014) A national survey of renal replacement therapy prescribing practice for acute kidney injury in Malaysian intensive care units. Nephrology, 19 8: 507-512. doi:10.1111/nep.12276

Cotta, Menino Osbert, Roberts, Jason A., Tabah, Alexis, Lipman, Jeffrey, Vogelaers, Dirk and Blot, Stijn (2014) Antimicrobial stewardship of β-lactams in intensive care units. Expert Review of Anti-Infective Therapy, 12 5: 581-595. doi:10.1586/14787210.2014.902308

Roberts, Jason A. and Roberts, Darren M. (2014) Antibiotic dosing in critically ill patients with septic shock and on continuous renal replacement therapy: can we resolve this problem with pharmacokinetic studies and dosing guidelines?. Critical Care, 18 3: . doi:10.1186/cc13939

Sime, Fekade Bruck, Roberts, Michael S., Warner, Morgyn S., Hahn, Uwe, Robertson, Thomas A., Yeend, Sue, Phay, Andy, Lehman, Sheila, Lipman, Jeffrey, Peake, Sandra L. and Roberts, Jason A. (2014) Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy. Antimicrobial Agents and Chemotherapy, 58 6: 3533-3537. doi:10.1128/AAC.02340-14

Roberts, Jason A., Udy, Andrew A., Bulitta, Juergen B., Stuart, Janin, Jarrett, Paul, Starr, Therese, Lassig-Smith, Melissa, Roberts, Natasha A., Dunlop, Rachel, Hayashi, Yoshiro, Wallis, Steven C. and Lipman, Jeffrey (2014) Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration. Journal of Antimicrobial Chemotherapy, 69 9: 2508-2516. doi:10.1093/jac/dku177

Roberts, J. A., Stove, V., De Waele, J. J., Sipinkoski, B., McWhinney, B., Ungerer, J. P. J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, K.-M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Starr, T., Wallis, S. C. and Lipman, J. (2014) Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DALI Study. International Journal of Antimicrobial Agents, 43 5: 423-430. doi:10.1016/j.ijantimicag.2014.01.023

De Waele, Jan J., Lipman, J., Akova, M., Bassetti, M., Dimopoulos, G., Kaukonen, M., Koulenti, D., Martin, C., Montravers, P., Rello, J., Rhodes, A., Udy, A. A., Starr, T., Wallis, S. C. and Roberts, J. A. (2014) Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients. Intensive Care Medicine, 40 9: 1340-1351. doi:10.1007/s00134-014-3403-8

Escobar, Leslie, Andresen, Max, Downey, Patricio, Gai, Maria Nella, Regueira, Tomas, Borquez, Tamara, Lipman, Jeffrey and Roberts, Jason A. (2014) Population pharmacokinetics and dose simulation of vancomycin in critically ill patients during high-volume haemofiltration. International Journal of Antimicrobial Agents, 44 2: 163-167. doi:10.1016/j.ijantimicag.2014.03.009

Avent, Minyon L., Hall, Lisa, Davis, Louise, Allen, Michelle, Roberts, Jason A., Unwin, Sean, McIntosh, Kylie A., Thursky, Karin, Buising, Kirsty and Paterson, David L. (2014) Antimicrobial stewardship activities: a survey of Queensland hospitals. Australian Health Review, 38 5: 557-563. doi:10.1071/AH13137

Roberts, Jason A., Abdul-Aziz, Mohd H., Lipman, Jeffrey, Mouton, Johan W., Vinks, Alexander ., Felton, Timothy W., Hope, William W., Farkas, Andras, Neely, Michael N., Schentag, Jerome J., Drusano, George, Frey, Otto R., Theuretzbacher, Ursula and Kuti, Joseph L. (2014) Individualised antibiotic dosing for patients who are critically ill: Challenges and potential solutions. The Lancet Infectious Diseases, 14 6: 498-509. doi:10.1016/S1473-3099(14)70036-2

Felton, T. W., Roberts, J. A., Lodise, T. P., Van Guilder, M., Boselli, E., Neely, M. N. and Hope, W. W. (2014) Individualization of piperacillin dosing for critically ill patients: Dosing software to optimize antimicrobial therapy. Antimicrobial Agents and Chemotherapy, 58 7: 4094-4102. doi:10.1128/AAC.02664-14

Shekar, Kiran, Fraser, John F. and Roberts, Jason A. (2013) Can optimal drug dosing during ECMO improve outcomes?. Intensive Care Medicine, 39 12: 2237-2237. doi:10.1007/s00134-013-3080-z

Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2013) Clinical implications of antibiotic pharmacokinetic principles in the critically ill. Intensive Care Medicine, 39 12: 2070-2082. doi:10.1007/s00134-013-3088-4

Adnan, Syamhanin, Paterson, David L., Lipman, Jeffrey and Roberts, Jason A. (2013) Ampicillin/sulbactam: Its potential use in treating infections in critically ill patients. International Journal of Antimicrobial Agents, 42 5: 384-389. doi:10.1016/j.ijantimicag.2013.07.012

Parker, Suzanne, Lipman, Jeffrey, Koulenti, Despoina, Dimopoulos, George and Roberts, Jason A. (2013) What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review. International Journal of Antimicrobial Agents, 42 4: 289-293. doi:10.1016/j.ijantimicag.2013.05.018

Putt, M. T., Udy, A. A., Jarrett, P., Martin, J., Hennig, S., Salmon, N., Lipman, J. and Roberts, J. A. (2013) Phenytoin loading doses in adult critical care patients: does current practice achieve adequate drug levels?. Anaesthesia and Intensive Care, 41 5: 602-609.

Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L., Starr, Therese, Udy, Andrew A., Paul, Sanjoy K. and Lipman, Jeffrey (2013) A protocol for a multicentre randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis: the BLING II study. Critical Care and Resuscitation, 15 3: 179-185.

Roberts, Jason A., Thorley, Bruce R., Bruggink, Leesa D. and Marshall, John A. (2013) Electron microscope detection of an endogenous infection of retrovirus-like particles in L20B cells. Journal of Electron Microscopy, 62 4: 485-486. doi:10.1093/jmicro/dfs133

Dulhunty, Joel M., Roberts, Jason A., Davis, Joshua S., Webb, Steven A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David L. and Lipman, Jeffrey (2013) Reply to Soman et al. Clinical Infectious Diseases, 57 2: 323-324. doi:10.1093/cid/cit201

Adnan, Syamhanin, Li, Janice Xuanhui, Wallis, Steven C., Rudd, Michael, Jarrett, Paul, Paterson, David L., Lipman, Jeffrey, Udy, Andrew A. and Roberts, Jason A. (2013) Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains. International Journal of Antimicrobial Agents, 42 1: 90-93. doi:10.1016/j.ijantimicag.2013.02.023

Roberts, Jason, Hobday, Linda, Ibrahim, Aishah, Aitken, Thomas and Thorley, Bruce (2013) Annual report of the Australian National Enterovirus Reference Laboratory 2010-2011. Communicable Diseases Intelligence Quarterly Report, 37 2: E105-E114.

Roberts, Jason, Hobday, Linda, Ibrahim, Aishah, Aitken, Thomas and Thorley, Bruce (2013) Annual report of the Australian National Enterovirus Reference Laboratory 2012. Communicable Diseases Intelligence Quarterly Report, 37 2: E97-E104.

Udy, Andrew A., Covajes, Cecilia, Taccone, Fabio Silvio, Jacobs, Frederique, Vincent, Jean-Louis, Lipman, Jeffrey and Roberts, Jason A. (2013) Can population pharmacokinetic modelling guide vancomycin dosing during continuous renal replacement therapy in critically ill patients?. International Journal of Antimicrobial Agents, 41 6: 564-568. doi:10.1016/j.ijantimicag.2013.01.018

Carlier, Mieke, Carrette, Sofie, Roberts, Jason A., Stove, Veronique, Verstraete, Alain, Hoste, Eric, Depuydt, Pieter, Decruyenaere, Johan, Lipman, Jeffrey, Wallis, Steven C. and De Waele, Jan J. (2013) Meropenem and piperacillin/tazobactam prescribing in critically ill patients: Does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used?. Critical Care, 17 3: R84.1-R84.9. doi:10.1186/cc12705

Mrara, B., Roberts, J. A. and Gowardman, J. (2013) Digoxin prescription in the critically ill: an unpredictably loaded problem?. Anaesthesia and Intensive Care, 41 3: 434-436.

Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2013) How should we dose antibiotics for pneumonia in the ICU?. Current Opinions in Infectious Diseases, 26 2: 189-195. doi:10.1097/QCO.0b013e32835d19e0

Kesson, Alison M., Choo, Chong Ming, Troedson, Christopher, Thorley, Bruce R. and Roberts, Jason A. (2013) Echovirus 19 associated with a case of acute flaccid paralysis. Journal of Paediatrics and Child Health, 49 3: E239-E242. doi:10.1111/jpc.12043

Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013) The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 7.1-7.10. doi:10.1186/1471-2253-13-7

Roberts, J. A., Hung, A. and Thorley, B. R. (2013) Letter to the editor: Application of bayesian methods to the inference of phylogeny for enterovirus surveillance. Eurosurveillance, 18 9: .

Hayashi, Yoshiro, Lipman, Jeffrey, Udy, Andrew A., Ng, Mandy, McWhinney, Brett, Ungerer, Jacobus, Lust, Karin and Roberts, Jason A. (2013) β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia. International Journal of Antimicrobial Agents, 41 2: 162-166. doi:10.1016/j.ijantimicag.2012.10.002

Roberts, Jason and Lipman, Jeffrey (2013) Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance and decreased bacterial susceptibility. Critical Care Medicine, 41 2: 489-495. doi:10.1097/CCM.0b013e31826ab4c4

Ranganathan, Dwarakanathan, John, George T., Healy, Helen, Roberts, Matthew J., Fassett, Robert G., Lipman, Jeffrey, Kubler, Paul, Ungerer, Jacobus, McWhinney, Brett C., Lim, Aaron, Purvey, Megan, Reyaldeen, Reza and Roberts, Jason A. (2013) A protocol for the pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN): An open-label, randomised controlled trial. BMJ Open, 3 8: . doi:10.1136/bmjopen-2013-003511

Semark, Andrew J., Venkatesh, Karthik, McWhinney, Brett C., Pretorius, Carel, Roberts, Jason A., Cohen, Jeremy and Venkatesh, Bala (2013) The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration. Critical Care and Resuscitation, 15 1: 63-66.

Roberts, Jason, Pea, Federico and Lipman, Jeffrey (2013) The clinical relevance of plasma protein binding changes. Clinical Pharmacokinetics, 52 1: 1-8. doi:10.1007/s40262-012-0018-5

Jamal, Janattul-Ain, Abdul-Aziz, Mohd-Haﬁz, Lipman, Jeffrey and Roberts, Jason A. (2013) Defining antibiotic dosing in lung infections. Clinical Pulmonary Medicine, 20 3: 121-128. doi:10.1097/CPM.0b013e31828fc646

Wong, Gloria, Briscoe, Scott, Adnan, Syamhanin, McWhinney, Brett, Ungerer, Jacobus, Lipman, Jeffrey and Roberts, Jason A. (2013) Protein binding of β-lactam antibiotics in critically Ill patients: can we successfully predict unbound concentrations?. Antimicrobial Agents and Chemotherapy, 57 12: 6165-6170. doi:10.1128/AAC.00951-13

Carlier, Mieke, Noe, Michael, De Waele, Jan J., Stove, Veronique, Verstraete, Alain G., Lipman, Jeffrey and Roberts, Jason A. (2013) Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients. Journal of Antimicrobial Chemotherapy, 68 11: 2600-2608. doi:10.1093/jac/dkt240

Beumier, Marjorie, Roberts, Jason A., Kabtouri, Hakim, Hites, Maya, Cotton, Frederic, Wolff, Fleur, Lipman, Jeffrey, Jacobs, Frederique, Vincent, Jean-Louis and Taccone, Fabio Silvio (2013) A new regimen for continuous infusion of vancomycin during continuous renal replacement therapy. Journal of Antimicrobial Chemotherapy, 68 12: 2859-2865. doi:10.1093/jac/dkt261

Dulhunty, Joel M., Roberts, Jason A., Webb, Joshua S., Webb, Steve A. R., Bellomo, Rinaldo, Gomersall, Charles, Shirwadkar, Charudatt, Eastwood, Glenn M., Myburgh, John, Paterson, David and Lipman, Jeffrey (2013) Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicentre double-blind, randomised controlled trial.. Clinical Infectious Diseases, 56 2: 236-244. doi:10.1093/cid/cis856

Udy, Andrew A., Roberts, Jason A., Shorr, Andrew F., Boots, Robert J. and Lipman, Jeffrey (2013) Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients. Critical Care, 17 1: R35.1-R35.9. doi:10.1186/cc12544

Abbott, Iain J. and Roberts, Jason A. (2012) Infusional beta-lactam antibiotics in febrile neutropenia: has the time come?. Current Opinion in Infectious Diseases, 25 6: 619-625. doi:10.1097/QCO.0b013e32835915c2

Smith, Nicholas L., Freebairn, Ross C., Park, Michael A. J., Wallis, Steven C., Roberts, Jason A. and Lipman, Jeffrey (2012) Therapeutic drug monitoring when using cefepime in continuous renal replacement therapy: seizures associated with cefepime. Critical Care and Resuscitation, 14 4: 312-315.

Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 29.1-29.9. doi:10.1186/1471-2253-12-29

Liu, Hong-Mei, Roberts, Jason A., Moore, Deborah, Anderson, Barbara, Pallansch, Mark A., Pevear, Daniel C., Collett, Marc S. and Oberste, M. Steven (2012) Characterization of poliovirus variants selected for resistance to the antiviral compound V-073. Antimicrobial Agents and Chemotherapy, 56 11: 5568-5574. doi:10.1128/AAC.00539-12

Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012) Sedation during extracorporeal membrane oxygenation-why more is less. Anaesthesia and Intensive Care, 40 6: 1067-1069.

Carlier, Mieke, Stove, Veronique, Roberts, Jason A., Van de Velde, Eric, De Waele, Jan J. and Verstraete, Alain G. (2012) Quantification of seven beta-lactam antibiotics and two beta-lactamase inhibitors in human plasma using a validated UPLC-MS/MS method. International Journal of Antimicrobial Agents, 40 5: 416-422. doi:10.1016/j.ijantimicag.2012.06.022

Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012) Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 3: 726-727. doi:10.1093/jac/dks435

Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012) Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 5: R194.1-R194.7. doi:10.1186/cc11679

Briscoe, Scott E., McWhinney, Brett C., Lipman, Jeffrey, Roberts, Jason A. and Ungerer, Jacobus P. J. (2012) A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 907 178-184. doi:10.1016/j.jchromb.2012.09.016

Jamal, Janattul-Ain, Economou, Caleb J. P., Lipman, Jeffrey and Roberts, Jason A. (2012) Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation. Current Opinion in Critical Care, 18 5: 460-471. doi:10.1097/MCC.0b013e32835685ad

Roberts, Jason A., Kuiper, Michael J., Thorley, Bruce R., Smooker, Peter M. and Hung, Andrew (2012) Investigation of a predicted N-terminal amphipathic α-helix using atomistic molecular dynamics simulation of a complete prototype poliovirus virion. Journal of Molecular Graphics and Modelling, 38 165-173. doi:10.1016/j.jmgm.2012.06.009

Abdul-Aziz, Mohd H., Dulhunty, Joel M., Bellomo, Rinaldo, Lipman, Jeffrey and Roberts, Jason A. (2012) Continuous beta-lactam infusion in critically ill patients: the clinical evidence. Annals of Intensive Care, 2 1: 37. doi:10.1186/2110-5820-2-37

Patel, Bhavik M., Paratz, Jennifer D., Mallet, Anthony, Lipman, Jeffrey, Rudd, Michael, Muller, Michael J., Paterson, David L. and Roberts, Jason A. (2012) Characteristics of bloodstream infections in burn patients: an 11-year retrospective study. Burns, 38 5: 685-690. doi:10.1016/j.burns.2011.12.018

Varghese, Julie M., Roberts, Jason A., Wallis, Steven C., Boots, Robert J., Healy, Helen, Fassett, Robert G., Lipman, Jeffrey and Ranganathan, Dwarakanathan (2012) Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD study). Clinical Journal of the American Society of Nephrology, 7 8: 1249-1256. doi:10.2215/CJN.12211211

Sime, Fekade Bruck, Roberts, Michael S., Peake, Sandra L., Lipman, Jeffrey and Roberts, Jason A. (2012) Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review. Annals of Intensive Care, 2 1: 35.1-35.11. doi:10.1186/2110-5820-2-35

Roberts, Jason, De Waele, Jan J., Dimopoulos, George, Koulenti, Despoina, Martin, Claude, Montravers, Philippe, Rello, Jordi, Rhodes, Andrew, Starr, Therese, Wallis, Steven and Lipman, Jeffrey (2012) DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic. BMC Infectious Diseases, 12 152.1-152.7. doi:10.1186/1471-2334-12-152

Kaur, Sukhpreet, Roberts, Jason A. and Roberts, Michael S. (2012) Evaluation of medication-related problems in medication reviews: a comparative perspective. Annals of Pharmacotherapy, 46 7-8: 972-982. doi:10.1345/aph.1Q694

Udy, Andrew A., Varghese, Julie M., Altukroni, Mahdi, Briscoe, Scott, McWhinney, Brett C., Ungerer, Jacobus P., Lipman, Jeffrey and Roberts, Jason A. (2012) Subtherapeutic Initial beta-Lactam Concentrations in Select Critically Ill Patients Association Between Augmented Renal Clearance and Low Trough Drug Concentrations. Chest, 142 1: 30-39. doi:10.1378/chest.11-1671

Roberts, Jason A. and Lipman, Jeffrey (2012) Closing the loop-a colistin clinical study to confirm dosing recommendations from PK/PD modeling. Clinical Infectious Diseases, 54 12: 1727-1729. doi:10.1093/cid/cis311

Dhanani, Jayesg, Roberts, Jason A. and Lipman, Jeffrey (2012) Antibiotic therapy of pneumonia in critical care. Current Respiratory Medicine Reviews, 8 3: 228-238. doi:10.2174/157339812800493232

Sinnollareddy, Mahipal G., Roberts, Michael S., Lipman, Jeffrey and Roberts, Jason A. (2012) beta-Lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: A structured review. Clinical and Experimental Pharmacology and Physiology, 39 6: 489-496. doi:10.1111/j.1440-1681.2012.05715.x

Udy, Andrew A., Roberts, Jason A., De Waele, Jan J., Paterson, David L. and Lipman, Jeffrey (2012) What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance. International Journal of Antimicrobial Agents, 39 6: 455-457. doi:10.1016/j.ijantimicag.2012.02.010

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I, Dunster, Kimble R., Fisquet, Kimble R, Platts, David G., Stewart, David G, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012) Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 2: 105-111.

Thorley, Bruce R. and Roberts, Jason A. (2012) The association of picornaviruses with gastroenteritis. Microbiology Australia, 33 2: 82-84.

Roberts, Darren M., Roberts, Jason A., Roberts, Michael S., Liu, Xin, Nair, Priya, Cole, Louise, Lipman, Jeffrey, Bellomo, Rinaldo and on behalf of the RENAL Replacement Therapy Study Investigators (2012) Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study. Critical Care Medicine, 40 5: 1523-1528. doi:10.1097/CCM.0b013e318241e553

Patel, Bhavik M., Paratz, Jennifer, See, Natalie C., Muller, Michael J., Rudd, Michael, Paterson, David, Briscoe, Scott E., Ungerer, Jacobus, McWhinney, Brett C., Lipman, Jeffrey and Roberts, Jason A. (2012) Therapeutic drug monitoring of beta-lactam antibiotics in burns patients-A one-year prospective study. Therapeutic Drug Monitoring, 34 2: 160-164. doi:10.1097/FTD.0b013e31824981a6

Roberts, Jason A., Joynt, Gavin M., Choi, Gordon Y.S., Gomersall, Charles D. and Lipman, Jeffrey (2012) How to optimise antimicrobial prescriptions in the Intensive Care Unit: principles of individualised dosing using pharmacokinetics and pharmacodynamics. International Journal of Antimicrobial Agents, 39 3: 187-192. doi:10.1016/j.ijantimicag.2011.11.002

Adnan, Syamhanin, Paterson, David, Lipman, Jeffrey, Kumar, Suresh, Li, Janice, Rudd, Michael J and Roberts, Jason (2012) Pharmacokinetics of beta-lactam antibiotics in patients with intra-abdominal disease: A structured review. Surgical Infections, 13 1: 9-17. doi:10.1089/sur.2011.046

Li, Janice, Udy, Andrew A., Kirkpatrick, Carl M.J., Lipman, Jeffrey and Roberts,Jason A. (2012) Improving vancomycin prescription in critical illness through a drug use evaluation process: a weight-based dosing intervention study. International Journal of Antimicrobial Agents, 39 1: 69-72. doi:10.1016/j.ijantimicag.2011.08.017

Abdul-Aziz, Mohd Hafiz, Staatz, C. E., Kirkpatrick, C. M. J., Lipman, J. and Roberts, J. A. (2012) Continuous infusion vs. bolus dosing: Implications for beta-lactam antibiotics. Minerva Anestesiologica, 78 1: 94-104.

Sinnollareddy, Mahipal, Peake, Sandra L., Roberts, Michael S., Lipman, Jeffrey and Roberts, Jason A. (2012) Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: A systematic review. International Journal of Antimicrobial Agents, 39 1: 1-10. doi:10.1016/j.ijantimicag.2011.07.013

Roberts, Jason (2012) Australian clinical pharmacy award oration. Journal of Pharmacy Practice and Research, 42 4: 308-310.

Shekar, Kiran, Fraser, John F., Smith, Maree T. and Roberts, Jason A. (2012) Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. Journal of Critical Care, 27 6: 741.e9-741.e18. doi:10.1016/j.jcrc.2012.02.013

Roberts, Jason A., Norris, Ross, Paterson, David L. and Martin, Jennifer H. (2012) Therapeutic drug monitoring of antimicrobials. British Journal of Clinical Pharmacology, 73 1: 27-36. doi:10.1111/j.1365-2125.2011.04080.x

Lonsdale, Dagan O., Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2012) Antibacterial therapeutic drug monitoring in cerebrospinal fluid: difficulty in achieving adequate drug concentrations. Journal of Neurosurgery, 118 2: 297-301. doi:10.3171/2012.10.JNS12883

Shekar, K., Roberts, J. A., Mullany, D. V., Corley, A., Fisquet, S., Bull, T. N., Barnett, A. G. and Fraser, J. F. (2012) Increased sedation requirements in patients receiving extracorporeal membrane oxygenation for respiratory and cardiorespiratory failure. Anaesthesia and Intensive Care, 40 4: 648-655.

Patel, Kashyap, Roberts, Jason A., Lipman, Jeffrey, Tett, Susan E., Deldot, Megan E. and Kirkpatrick, Carl M. (2011) Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration - using Monte Carlo Simulations to predict doses for specified pharmacodynamic targets. Antimicrobial Agents and Chemotherapy, 55 12: 5868-5873. doi:10.1128/AAC.00424-11

Roberts, Jason A. (2011) Importance of Antibiotic Dosing in Critically Ill Patients. Current Pharmaceutical Biotechnology, 12 12: 1981-1982. doi:10.2174/138920111798808310

Roberts, Jason A. (2011) Using PK/PD to Optimize Antibiotic Dosing for Critically Ill Patients. Current Pharmaceutical Biotechnology, 12 12: 2070-2079. doi:10.2174/138920111798808329

Sinnollareddy, Mahipal, Peake, Sandra L., Roberts, Michael S., Playford, E. Geoffrey, Lipman, Jeffrey and Roberts, Jason A. (2011) Pharmacokinetic evaluation of fluconazole in critically ill patients. Expert Opinion On Drug Metabolism and Toxicology, 7 11: 1431-1440. doi:10.1517/17425255.2011.615309

Lipman, J., Udy, A. and Roberts, Jason (2011) Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story. Anaesthesia and Intensive Care, 39 6: 999-1000.

Douglas, Alexandra, Udy, Andrew A., Wallis, Steven C., Jarrett, Paul, Stuart, Janine, Lassig-Smith, Melissa, Deans, Renae, Roberts, Michael S., Taraporewalla, Kersi, Jenkins, Jason, Medley, Gregory, Lipman, Jeffrey and Roberts, Jason A. (2011) Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery. Antimicrobial Agents and Chemotherapy, 55 11: 5238-5242. doi:10.1128/AAC.05033-11

Udy, Andrew A., Roberts, Jason A. and Lipman, Jeffrey (2011) Implications of augmented renal clearance in critically ill patients. Nature Reviews Nephrology, 7 9: 539-543. doi:10.1038/nrneph.2011.92

Martin, Jennifer H., Fay, Michael F., Udy, Andrew, Roberts, Jason, Kirkpatrick, Carl, Ungerer, Jacobus and Lipman, Jeffrey (2011) Pitfalls of using estimations of glomerular filtration rate in an intensive care population. Internal Medicine Journal, 41 7: 537-543. doi:10.1111/j.1445-5994.2009.02160.x

Roberts, Jason A., Taccone, Fabio Silvio, Udy, Andrew A., Vincent, Jean-Louis, Jacobs, Frederique and Lipman, Jeffrey (2011) Vancomycin Dosing in Critically Ill Patients: Robust Methods for Improved Continuous-Infusion Regimens. Antimicrobial Agents and Chemotherapy, 55 6: 2704-2709. doi:10.1128/AAC.01708-10

Baptista, Joao P., Udy, Andrew A., Sousa, Eduardo, Pimentel, Jorge, Wang, Lisa, Roberts, Jason A. and Lipman, Jeffrey (2011) A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance. Critical Care, 15

Professor Jason Roberts

Researcher biography

Publications

Book Chapters

Journal Articles