Administration of beta-lactam antimicrobials by continuous infusion has been proposed as an intervention to improve pharmacokinetic/pharmacodynamic target attainment of these compounds in patients with severe sepsis and septic shock.

This study will be powered to mortality (an important patient-centred outcome). The proposed clinical study will be submitted to the NHMRC for Project Grant funding consideration in 2016 as well as to Canadian and European funding bodies.

Project members

Professor Jason Roberts

Chief Investigator and CRE lead

Professor Jeffrey Lipman

Chief Investigator

Professor John Myburgh

Associate Investigator

Professor Rinaldo Bellomo

Associate Investigator

Professor David Paterson

Associate Investigator

Professor Jan De Waele

Chief Investigator