Objective 5 seeks to undertake targeted clinical trials to determine the effect of PK/PD-guided interventions on clinical outcomes.

The following projects will be carried out to respond to objective 5:

Project 11. Continuous versus intermittent beta-lactams administration in critically ill patients with sepsis not receiving renal replacement therapy.  

Project 12. Therapeutic drug monitoring and dose personalisation of antimicrobials in mechanically ventilated patients with Gram-negative pneumonia.